Beth - I am not a doctor, but I would think the answer to your question "Is it life threatening if a person in a very toxic state is repeatedly treated with another toxin?" would have to be Yes.

For example:

http://www.firstconsult.com/das/pdxmd/body/235308051-43/0?type=med&eid=9-u1.0-_1_mt_1010017

Re Life threatening Neuroleptic Malignant Syndrome from dopamine-blocking medications, antipsychotic agents.

http://www.nytimes.com/2007/02/27/health/27brody.html?ei=5124&en=4debc4fa3f838779&ex=1330837200&partner=permalink&exprod=permalink&pagewanted=print

Re Life threatening Serotonin Syndrome from drugs that raise serotonin levels, SSRI antidepressants and some others.

http://www.countercurrents.org/pringle080507.htm

Re Doctors failing to recognise life-threatening serotonin syndrome and how "medical experts are "scrambling to educate doctors" about this.

Very good question - Why do doctors not recognise and act on the knowledge of these effects and potentially fatal reactions?
There are many who monitor this forum who can give the answer but sadly if they do those who have a vested interest in hiding the dreadful truth will target them.
Here in the UK many patients have tried to persuade the General Medical Council, Members of Parliament, and the Police to investigate the doctors who have hidden cases of poisoning by drugs, pesticides and vaccines and fraudulently blamed the symptoms on mental illness but the GMC and all other authorities, including the Police, have refused to get involved.
Should doctors speak out, expose the wrong doing, and offer alternative treatments they will find that those same powerful forces will turn on them in attempts to limit the damage to powerful international companies, which have, via the approvals and licensing systems, passed liability for faulty product to the various governments, which in turn accept safety data without ever checking them for accuracy.
The only way that these crimes against humanity can be exposed is through the media and the courts but they too are controlled, as many of us have found to our cost.
We can only hope that the many honest but fearful doctors and scientists in this world will find a way to counter the power and get the information to the patients who need to know – for their lives, and sanity, depend upon it.

"We can only hope that the many honest but fearful doctors and scientists in this world will find a way to counter the power and get the information to the patients who need to know – for their lives, and sanity, depend upon it".

Yes RBruceUK - I hope everyone here agrees that so many lives do depend on fearful doctors and scientists countering the power and getting the information to the patients.

When they find the courage they will also find a way to take a stand alongside the lone brave individuals like Yola and take the huge step it must take in this day and age to become true to themselves and to what they once believed in, which in medicine is to "Above all, Do No Harm".

bruceUK,

I am very interested in epigentics but have trouble getting answers even from Karolinska, I know a person, a Poor Metabolizer 2D6*4*4 who was toxic on paroxetine then high dose venlafaxine for years and gave birth to a child with Angelman's syndrome, genetic proof, having taken paroxetine throughout her pregnancy. One of my books says Angelman's syndrome is an epigenetic problem.

The child has, without detailed examination, the same heart and head bone problems as Paroxetine babies have, will not go into detail here. Can you advise where I can learn more about this, and thank you for your contribution.
I value your opinion please and sources of further information

Epigenetics has been developing since 1947. Now seems more focused on causal interactions between genes and their products and the changes in cells and formation, which can be transmitted through the generations. Defined as “the study of heritable changes that occur without a change in the DNA sequence”.
Over 5 years ago a UK study on Epigenetics reported that environmental influences over our grandmothers when they were still in their mother's wombs (the eggs are viable) and those same influences over our grandfathers at puberty can trigger changes in the genetic makeup that will be passed down for generations to come.
Another example of drug induced effects on the unborn is DES.
DES (diethylstilbestrol) was a synthetic oestrogen regarded as a wonder drug used to prevent miscarriages and premature births in an experiment on some 5 million women. It was intended for routine use in all pregnancies and for menopausal symptoms, acne, prostate cancer, gonorrhoea, as a growth regulator to slow girls who were growing too tall and as a "morning after pill", even as a food additive on farms.....Then rat studies began to show abnormalities.
Rare vaginal cancers began appearing not in the treated women but in the teenage children born to them.
Later it was suspected of causing fertility and immune system problems and testicular cancer in male children also born to treated mothers. Daughters of treated women were reported to show permanent changes in the T and natural killer cells of the immune system and yet they did not show greater vulnerability to infection.
The claim was that the delayed long-term effects that did not show until later in life were previously unrecognised medical phenomena.

http://en.wikipedia.org/wiki/Epigenetics

Bruce You might be interested in this response from Wendell Weber to the same question:Next thing is to find paroxetine affected progeny and see if they have Angelman's syndrome
You asked 1) whether Angelman's syndrome (AS) is an epigenetic
problem, and 2) whether paroxetine in a homozygous CYP2D6 poor
metabolizer (allele 4:allele 4) with or without alcohol intake can cause AS?

As to the first question: The review by B. Horsthemke and J. Wagstaff
(2008) that considers "Mechanisms of imprinting of the
Prader-Willi/Angelman region" states that AS is a distinct
neuodevelopmental disorder caused by several genetic and epigenetic
mechanisms caused by several genetic and epigenetic mechanisms
involving the proximal arm of chromosome 15. Lack of a functional
maternal copy of ubiquintin ligase 3A (UBE3A), a gene within
chromosome 15q11-q13, causes AS. Individuals with AS exhibit
microcephaly, ataxia, severe mental retardation, seizures, absence od
speech and sleep disorder (CA Willaims et al, 2006). Seventy percent
of AS individuals have large de novo deletions of 15q11-q13, but in
AS individuals, these de novo deletions are always of maternal
origin. Five to 10% of AS individuals have point mutations 0f the
UBE3A gene within 15q11-q13 which has led to identification of UBE3A
as the AS gene. Three to 5% of AS individuals have an imprinting
defect, wuith a meaternally inherited chromosome 15 that has a
paternal imprint, and 1-2% of AS individuals have paternal
uniparental disomy of chromosome 15. There are still a number of
major unanswered questions about the imprinting process which
Horsthemke and Wagstaff discuss.

As to the second question: I have done a Google search looking for a
causative link between paroxetine-induced birth defects (in the
presence and absence of alcohol intake) and AS. Those searches were
not exhaustive but insofar as they went, they did not yield any
useful information. Despite that negative information, they do not
necessarily rule a possible connection

I hope these comments are a some help in response to your queries