Richard has a very good point here: organism is a complex mechanism and all processes are related. However, cytochrome P450 system is the first line of defence in detoxification system. Hence, all impairments in this system should be taken in consideration. (most important they are easy detected and can be used in clinical practice). Phase 1 cytochrome P450 loss-of-function polymorphisms should be included in patient record warning labels, similar to allergies, as a warning that an individual patient is susceptible to adverse drug reactions or has a limited capacity for elimination of toxins, leading to the development of allergies or toxicity. In addition, this system participates in the metabolism of environmental toxins making individuals with loss-of-function polymorphisms susceptible to the development of allergies and metabolic diseases.

I recall a bright drug user with a drug induced psychosis to speed saying to me;

"Surely you are not going to treat a toxic state with another toxin."

He was of course right and I did not.

Just gave lots of fluids gave lots of fluids, and he detoxed faster than he might have done with Risperdal or Zyprexa which need the same metabolic pathways as amphetamines.

Since then I learnt that those who get toxic psychosis on amphetamines whether they were illegally obtained or prescribed, also have diminished CYP450 metabolism genes and get worse if you give them more drugs.

Time and talking them down fixes it.

The drug culture knows this but psychiatrists do not.

I don't know if parts of this group of videos might also be useful to Bruce (Richard?).

Its a kind of lecture in 13 bite-sized chunks with the last few being the lecturer answering questions by members of the 'audience'.

This is the video of Part 1 of 13
Dr. Veltmann, Personalized Genomics

http://www.youtube.com/user/iimsite#p/u/12/plgmnlpq4Xc

If that looks as if it might touch on areas Richard is referring to, then the complete set of videos in numerical order is here:

http://www.youtube.com/results?search_query=iimsite&aq=f

WHOOPS! I think its Video number 2 that I have a feeling MIGHT touch on what Richard is saying because Dr Veltmann goes into how environmental factors and nutrients can change phenotypic expression.

I'd watch Video 1 first anyway as its more of an introduction and leads up to Video 2, as it may have some of this nutrient and environmental in it as well (tired and can't remember clearly, sorry) and I might be completely on the wrong track as to whether its pointing in part to what Richard is saying, but here's a link to Video 2 (or Part 2) anyway:

http://www.youtube.com/user/iimsite#p/u/3/xWmC4Z7dnYw

This issue is much more complex than personal genomics, and the chemical companies have been utilising the science to develop their drugs and industrial/agricultural chemicals for decades.
Sadly the approvals system prioritises proof of beneficial effects on the problem to be treated, but suppresses or hides the adverse effects that are triggered by those same chemicals that may even lead to deaths.
Protein creation, and enzyme blocking or bonding mechanisms are the basis for all these reactions and there are few, if any, chemicals that have only one effect.
“Proteins carry information in their shape and chemical structure: change either of these and you change the information carried by the protein… Nature’s favourite way of changing the shape or chemical structure of a protein is to stick a phosphate group onto its surface or to remove one …”
Frequently generic chemicals have different properties and side-effects to branded versions because of actions triggered by other chemicals in the formulations and additionally the very detox mechanisms that are there to protect us can themselves convert the poisons into even more toxic substances that will bond to and disrupt other vital enzymes as metabolites are formed.
All this is known but studies of proteomics and genomics are mostly used to find new drugs and chemicals to solve the problems caused by the initial disruption of the system.
Although the study of Epigenetics is growing in importance there is very little research being done to determine the actual cause of the genetic and protein mutations that have triggered the problems and when causes are found, as in the pharmaceutically-induced iatrogenic cases of CJD via the injection of mutated proteins into healthy people, (and the TGN 1412 drug trial disaster), every effort is made to suppress the truth in order to protect industry.
Effects of toxins on the mitochondria, proteolytic enzymes, and the various forms of RNA and DNA, can have devastating results, triggering such diverse illnesses as Schizophrenia, Parkinson's, cancers, etc., and the very anomalies with the detox and control systems discussed here that are designed to prevent such problems.

Is it life threatening if a person in a very toxic state is repeatedly treated with another toxin?

I trust the doctors here for a clear answer and not in jargon please.

The posts about death statistics overwhelm me at times because so many of the people I know are drugged with prescription medication. Often with debilitating side effects.

You people have the answers and still nothing is happening!
How can we change things? Perhaps the hope that good will conquer evil
but in our world today it's a big ask but if we lose hope we are lost.