As I was reading this article, for some reason I could not avoid thinking of scientology. Dr Lucire's views would align very nicely with scientologists' views that psychiatry is dangerous and mental illness does not need drug treatment. Well, read this - http://www.scara-mouche.com/?p=114

I'm amazed that nobody has commented on this very important subject.

I remember not all that long ago whereby big pharmaceutical companies where taken to task for bribing Australian doctors with anything from pens, all the way through to golf clubs and expensive overseas holidays and all in an attempt to have those doctors push their particular brand of drugs.

As someone who works in mental health, I once asked a doctor why he'd prescribe a product whose own company didn't even know how that drug worked. He was rather rude when he asked "exactly what do you mean by that?" I pointed out that the spiel on the back of the packet of a particular antidepressant he'd prescribed said...... "This product is thought to work by......" The literature went on in an attempt to explain the relationship between lack of serotonin and it's effect on mental stability, however it was the words "thought to work by" that I pointed out to him. If a doctor was trying to get me to take pills where the producing company only "thought" it knew how it's own product worked, then I'd be looking for another doctor. Needless to say he snorted a indecipherable response and stormed out of the office.

The point is, as the article demonstrates, too many doctors are using drugs put out by pharma companies where the documented evidence of non harm and an acceptable patient outcome simply doesn't stack up. It's equally unfortunate that many of these doctor's patients are in a vulnerable condition at the time of prescription and their knowledge of adverse drug reaction and poly pharmacy is near to non-existent.

Good article Peter King. My only wish is that it doesn't get relegated to the dust-bin of history. This is a very important story, but one I fear that is simply the tip of the ice-berg.

A recent book that supports Dr Yolande Lucire's concerns is "Anatomy of an Epidemic" by Robert Whitaker (2010)

http://www.robertwhitaker.org/robertwhitaker.org/Anatomy%20of%20an%20Epidemic.html

Available at amazon.com

Anatomy of an Epidemic investigates a medical mystery: Why has the number of adults and children disabled by mental illness skyrocketed over the past fifty years?

The modern era of psychiatry is usually said to have begun with the introduction of Thorazine into asylum medicine in 1955. This kicked off a “psychopharmacological revolution,” or so our society is told, with psychiatry discovering effective drugs for mental disorders of all kinds. In 1988, the first of the “second-generation” psychiatric drugs--Prozac--was introduced, and these new drugs were said to represent another therapeutic advance. Yet, even as this “psychopharmacological revolution” has unfolded over the past 50 years, the number of people disabled by mental illness has soared.

In 1955, there were 355,000 adults in state and county mental hospitals with a psychiatric diagnosis. During the next three decades (the era of the first generation psychiaric drugs), the number of disabled mentally ill rose to 1.25 million. Prozac arrived on the market in 1988, and during the next 20 years, the number of disabled mentally ill grew to more than four million adults (in 2007.) Finally, the prescribing of psychiatric medications to children and adolescents took off during this period (1987 to 2007), and as this medical practice took hold, the number of youth in America receiving a government disability check because of a mental illness leapt from 16,200 in 1987 to 561,569 in 2007 (a 35-fold increase.)

Theis astonishing increase in the disability numbers during the past fifty years raises an obvious question: Could the widespread use of psychiatric medications be fueling this epidemic?

Anatomy of an Epidemic investigates that question by focusing on the long-term outcome studies in the research literature. Do the studies tell of a paradigm of care that helps people get well and stay well over the long term? Or do they tell of a paradigm of care that increases the likelihood that people diagnosed with mental disorders will become chronically ill?

Well worth reading!

Clearly this Doctor is 'evil'. How dare she target the poor defenceless mega billionaire run pharmaceutical industry? So what if a few hundred or even a few thousand suffer due to this or that medication? They'll just get another one, not on the PBS.

The truth is that this industry is too powerful, too influential and far too dangerous to be allowed any measure of self regulation.

The federal government should establish an Aussie version of the FDA with teeth, but do you see that happening?

Very interesting article on the courageous, intelligent and original Yola Lucire. Her work in uncovering this corrupt mess is of a piece with her PhD on RSI, which showed a massive corrupt culture involving doctors, unions and insurance companies; all profiting downstream from the government-granted privileges of the medical guild with its snout in the OHS trough.

The article shows the corrupt interrelation of big government with big business that is the inevitable outcome of interventions intended to regulate and subsidise "health" care.

It is important to understand that this kind of corrupt mess *cannot ever* be avoided with the combination of
a) government subsidising and licensing medical training, licensing and compulsory insuring of doctors, subsidising health care, providing "free" medical services for all, subsidising pharmaceutical benefits, and regulating pharmaceutical developments, and
b) definitions of medical conditions by a medical profession whose very existence is dependent in innumerable ways on government status, privileges, insurances, favours and subsidies, and
c) medicines provided by private corporations to government-set standards with a view to profit.

It is easy to get confused in the welter of ethical, technical, economic and political issues. But we should never lose sight of the original value - the health and individual responsibility of the patient, however his discretion may be delegated in some degree to his doctor.

There is no way in the world these problems can be fixed by more regulation. It is indeed the chimera of governmental universal wisdom, competence and benevolence that has allowed the corruption to take this particularly insidious form, protected by the authority and status of government-qualified and -sponsored vested interests. Their sinecures are too comfortable for them to condescend to intellectually honest inquiry, and why should they?

Even if the political will existed to "fix" the problem, exactly how can that be done by rules, regulations, and bureaucracies without importing all the original problems of knowledge and power?

Predictably someone (anaminx) has raised the Scientology spectre.
The Citizens Commission on Human Rights, which was jointly founded by Scientology and psychiatrist Thomas Szasz, makes many valid claims criticising psychiatric drugs and relationships between psychiatry and drug companies. Many critics of antidepressants (myself included) would agree with many of CCHR's evidence-based claims. But most critics of antidepressants (myself included) are not, have never been, and never will be Scientologists.
Robert Whitaker, author of 'Anatomy of an Epidemic', has suggested that the pharmaceutical industry may have encouraged Scientology to criticise them, in order to tarnish perceptions about critics collectively. I think he is probably right.

Good article
I have thought that there could be a link between suicide and some homicides and prescribed drugs. I have observed someone who has mental problems but refuses to take prescription drugs and that person seems to have found ways to cope without drugs. She told me that she has identified what triggers her stress and now has a better perspective of her illness. This person never took prescription drugs at all and did have a personal battle but after a period of ten years now leads a reasonable life. Not everyone is the same however.

4freedom has hit the nail on the head - everyone is different. I also know a man with a mental illness, While he is taking his medication he is fine and a great guy. A couple of times he has tried to go without. The consequences were astounding, he becomes aggressive and completely irresponsible.

In my own case I became very depressed after a serious illness. Apparently this is not an uncommon occurrence after illness or body trauma- witness postnatal depression. I took drugs and not only me but also those around me noticed a huge difference. They do work for some.

Maybe the fault lies with those who prescribe the drugs. Is the patient given regular reviews as with, say, heart medication? Or is it the case that the drug is prescribed and the condition is considered automatically cured? I agree that the pharmas wield a huge amount of influence but their products do help some and a much more detailed investigation of the issues raised is needed.

Having lost my career and my health to paroxetine induced serotonin syndrome, and watch a psychiatrist who prescribed over double the *maximum* receive a stern letter I found myself involved in the global pursuit of GSK with Elliot Spitzer [then] AG of NY and UK MP's. I studied David Healy's work and accessed internal documents. As a trained scientist and critical thinker, I found ultimately I still could, indeed must, trust only the evidence before me.

My conclusion? The persecution of "Big Pharma" is a phoney industry buoyed by conflicts of interest, sour grapes, pseudoscience, ignorance of business dynamics and share holder rights, the billion dollar "wellness industry", science illiteracy in Western nations and the need to apportion blame.

This article skirts with irresponsibility close to an outrageous condoning of the entire Big Pharma conspiracy. Why has mental illness "skyrocketed"? For much the same reason the "epidemic" of autism is caused by vaccines - the very staple of Big Pharma/Big Brother paranoia.

It hasn't and isn't. We now have definitive diagnostics and an approach that is inclusive of the intellectually challenged and psychologically disabled. A return to the days of Asylums, physical restraint, electro-shock therapy and straight-jacketing the "criminally insane" instead of the - admittedly imperfect - De-institutionalisation in modern societies is abhorrent to consider.

With autism we see an expanded diagnostic approach such that we now have an entire Spectrum of autistic disorders as opposed to one devastating criterium. Even with Wakefield exposed as a fraud and criminal, he remains a martyr figure for the conspiracy theorists. Their staple? "Big Pharma".

To allude that the TGA fails Australians re pharmaceuticals when it lacks the teeth to prevent mystical cancer cures, homeopathy, quality control-free herbal preparations, reflexology, acupuncture, mesotherapy, homeoprophylaxis, iridology, homotoxicology, crystal vibration therapy, and just recently "harmonic energy bracelets" is offensive.

Depressed patients attempt suicide. Correlation with med's is not causation. This mistake was made by Hon. Paul Flynn UK member for Newport West, made worse by the fact suicide during *recovery* is a known symptom predating SSRI's.

This is a worthy area. But far from realistic.

Data, can be “cooked” (a process which mathematician Charles Babbage in 1830 defined as “an art of various forms, the object of which is to give to ordinary observations the appearance and character of those of the highest degree of accuracy”.
As early as 1830 Charles Babbage discussed the deplorable decline of science in England by mentioning a variety of ways in which empirical data could be manipulated by irresponsible investigators. In the following submission I wish to address some of the tortious issues that may arise with respect to pharmaceutical companies manipulating clinical trial data to have their harmful products deemed safe by industry professionals and consumers. In the first instance I raise issues relating to Negligence, duty of care and standard of care.
Although some reports may suggest that pharmaceutical companies are all honest and ‘upfront’ in their dealings, other reports from media agencies may attempt to minimise the true magnitude of neglect to a ‘few bad apples’. Daniele Fanelli suggests this issue is much more widespread, and claims that it may be seen as the ‘tip of the iceberg as many frauds are never discovered’. For instance, “routine data audits conducted by the United States Food and Drug Administration between 1977 and 1990 found flaws in 10-20% of studies, some of these flaws led to 2% of clinical investigators judged guilty of serious scientific misconduct”.
Hang in there Gal

The problem in Australia is pharmaceutical corporations are not adequately held accountable for failures to warn consumers (including Doctors) accurately about the level and potential side effects of their products. Indeed, the harmful consequences of taking the medication such as antidepressants (also known as Selective Serotonin reuptake inhibitors [SSRI’s]) may substantially surpass their benefit. The implications of manipulating research data bears profound consequences upon those who are likely to be harmed by medication that has been derived from faulty information or fraud. The grave concerns surrounding this type of fraud are that it presents an alternate reality, one that is fraudulent and created under the semblance of scientific testing that is no better than playing a game of ‘pin the tail on the donkey’ whilst blindfolded.
Gal!

Let us take the following example to highlight the concerns I have. With respect to the benefits of pharmaceutical products, there is also a growing consensus based upon experts that pharmaceutical companies are fabricating and falsifying clinical trial data in order to sell their harmful products to an unsuspecting public. For instance, known risks identified in clinical trials such as suicidal ideations and adolescent homicides have been associated with the taking of psychopharmaceuticals. Other problems that influence the market place involve large transnational pharmaceutical corporations.
Gal!

In Australia, a cursory investigation into the product information guide from the ‘official Eli Lilly’ website for Zyprexa (Olanzapine) in the USA informs uses and patients of side effects such as “Increased Mortality in Elderly Patients with Dementia Related Psychosis”; “Suicidality and Antidepressant Drugs”; “Clinical Worsening and Suicide Risk” and amongst others – “Life-threatening Serotonin Syndrome which include symptoms of Akathisia”. (Eli Lilly, Zyprexa Olanzapine. (2010) <http://www.zyprexa.com/Pages/index.aspx> at 20 September 2010 see also P.D Whitehead, ‘Causality and Collateral estoppel: Process and content of recent SSRI Litigation’. (2003) Journal of American Academy Psychiatry and Law 31,(3) 377, 377).
Indeed, the information at the bottom of the official website states, “This site is intended for US residents aged 18 and over”.( (Eli Lilly, Zyprexa Olanzapine. (2010) <http://www.zyprexa.com/Pages/index.aspx> at 20 September 2010 see also P.D Whitehead, ‘Causality and Collateral estoppel: Process and content of recent SSRI Litigation’. (2003) Journal of American Academy Psychiatry and Law 31,(3) 377, 377).
Equally important from an Australian context is the same drug (Zyprexa) and its product information leaflet is being sold without the warnings of suicide, and associated risks listed above.

I have a question: does Australia have libel laws?

As a student of internet libel law, I would suggest moderators here check out their risk in publishing comment #1

Dr Lucire has identified an important area of concern.

Dr Lucire has more courage than the sum total of those persecuting her.

It is very easy to stand up for all that has become accepted as good and right, we can all do that - it makes us feel happy, a part of a whole in a great society. In some cases standing up for, and even promoting the idea of, what is good and right brings far greater benefits. Higher positions in life. Billions of dollars profits. And the rest.

However, it takes one brave person with idealism, altruism and a lot of guts to speak out when serious flaws are seen - particularly where the evidence shows that by taking a stand to protect others, life is going to become very hard indeed.

There is plenty of evidence out there to support Dr Lucire. Some of it comes from previously hidden documents from clinical trials.

Where there are documents proving that deception and fraud have been flying under the banner of science, there are always going to be people who want it kept under wraps for their own sake. The same goes for all kinds of fraud - its done because it WORKS and it brings a benefit to those who commit the fraud.

Dr Lucire is doing what everyone who has responsibility for the health and safety of patients should be doing. Why are those persecuting her not doing so too?

One of very many documents that evidence dishonesty in clinical trials. Dated 1983.
http://www.ssri-uksupport.com/PfizerZoloft1983.pdf

It takes quite some courage to challenge the crimes committed by psychiatry and the pharmaceutical companies. Yes we can definitely say CRIMES considering everything that has been revealed in the US the last two years. A recent report by Public Citizen tells it all: overcharging government health programs; illegal promotion; anti-trust violations; kickbacks; concealing clinical trial findings; poor manufacturing practices; environmental violations; financial violations and illegal distribution.overcharging government health programs; illegal promotion; anti-trust violations; kickbacks; concealing clinical trial findings; poor manufacturing practices; environmental violations; financial violations and illegal distribution.

We can expect that Dr. Lucire's data about the lethal psychiatric drugs will be accepted as very true in the near future.

The simple question is, what genuine SCIENTIST would look at documents like this:

http://www.ssri-uksupport.com/PfizerZoloft1983.pdf

and say

Hey man, they listed a guy who was dismissed from a trial because he became HOMICIDAL and SUICIDAL after less than 2 weeks on a drug as actually being dismissed from the trial for "treatment failure and nausea" - but hey, thats OK, we have no scientific problem with that, bring on the drug as efficacious and safe regardless of how many patients that may kill ??

NO GENUINE SCIENTIST would agree to that.

So who is the scientist here?

Dr Lucire isn't happy about that kind of dishonest 'science'. But apparently the people who are supposed to be protecting patients who take the drug cannot be bothered to question it and want to make some kind of example of a genuine scientist who actually does care about the patients that the drug might harm, in order to protect them ?

A GENUINE scientist CARES about scientific integrity. Without it there is no science and, in medicine, lives are put at risk.

Give me a doctor any day that actually cares about what any drug might do. A doctor with integrity will be aware that there is a problem for some people and keep an eye out for symptoms of problems arising and know how to avoid it.

But I suppose that is it because I prefer SCIENCE to fraud and deceipt.

Thank goodness someone is speaking out in support of Dr Lucire. She is a real altruistic warrior. The attempts by 'authorities' to silence her thus far have been entirely abhorrent.

One might be forgiven for mistaking a couple of comments here as coming straight from BigPharma HQ. To me, such points of view indicate just how much society has been sucked in by the spin of this industry; an industry given far too much control over the dissemination of information about mental illness and its treatments.

Further evidence of BigPharma's influence is in the frequent suggestions that someone must be Scientology-associated for speaking out about bad practice and standing up for what is right.

Only when you have suffered the hellish manifestations of the 'imaginary science' referred to by the author can you truly comprehend its diabolical consequences. I for one will be always indebted to those gutsy professionals bucking trends and blowing whistles. It may not be immediately apparent, but you are saving lives.

These publications provide evidence that psychiatric drugs have a nasty side effect, suicide. They cause akathisia, restlessness, violence, homicide, toxic psychosis, weird behaviours, memory problems. Many drugs cause akathisia in some patients: some akathisiacs kill themselves or others: suicide and violence occur in medicated stress, not only mental illness. Akathisia is explained by pharmacogenetic tests.
1. Australian and New Zealand Journal of Psychiatry 38 11-12 933 2004 Burgess et al.
Do nations' mental health policies, programs and legislation influence their suicide rates? An ecological study of 100 countries.
Objective: To test the hypothesis that the presence of national mental health policies, programs and legislation would be associated with lower national suicide rates.
Method: Suicide rates from 100 countries were regressed on mental health policy, program and legislation indicators.
Results: Contrary to the hypothesized relationship, the study found that after introducing mental health initiatives (with the exception of substance abuse policies), countries' suicide rates rose.
Conclusion: It is of concern that most mental health initiatives are associated with an increase in suicide rates.
2. British Journal of Psychiatry ( 2006 )188 , 223 - 228
Lifetime suicide rates in treated schizophrenia: - 1875-1924 and 1994-1998 cohorts compared. Healy et al.
Background Recent interest in suicide rates in schizophrenia has been considerable.
Aims To establish the lifetime suicide rate from the pre-chlorpromazine era and to compare this with recent lifetime suicide rates for schizophrenia.
Method We have compared suicide and suicide attempt rates for 741 admissions for schizophrenia and 1303 admissions for psychoses to the North Wales Asylum between 1875 and 1924, with first admissions for psychosis in North West Wales between 1994 and 1998.
Results the suicide rate in schizophrenia between 1875 and 1924 was 20 per 100,000 hospital years, a lifetime rate of less than 0.5%. The suicide rate for all psychoses was 16 per 100,000 hospital years.
Current rates of suicide for schizophrenia and other psychoses appear 20-fold higher.
Conclusions: these findings point to an increase in suicide rates for patients with schizophrenia.
To understand how: watch this video.
http://www.youtube.com/watch?v=X53r3zTQJNk

and Google up akthsisia suicide, homicide and pharmacogenetics

@ Yola

'To understand how: watch this video.
http://www.youtube.com/watch?v=X53r3zTQJNk '

Thank you. Excellent video. Dr Healy clearly explains in a scientific way that is also easy to follow and understand.

There is interest in what is called the Americanization of Mental Health.
http://www.nytimes.com/2010/01/10/magazine/10psyche-t.html

If you looked at particularly magazines aimed at women, there are heaps of pop psychological articles. Take this test "see if your relationship will survive" or "how to be happy" or "how to have a happy relationship"

There is a subtle form of brain washing that perhaps even the authors are not aware of.

Welcome to Democracy - "Democracy can be seen as two wolves sitting at dinner table with a lamb/Sheep arguing about what is for dinner".

In this case, the sheep are people and the wolves represent the hegemonic view where all people are diseased and sick. No one can be normal anymore, there is a disease name for all human interactions. Lets not forget what 'may' be the pre-designed pill to cure these interactions.

What is sad is how can society move forward when the system is backwards. 'Its like wiping your bottom before you poo'.

Bring in Whistleblower protections so people like Yola can be sparred for acting honestly and in the best interests of people and not Profits. (Doesn't really say much about those "Other" so-called professionals that suport this greedy/parasitic system).

After what Julian Assange has released about our media machine not willing to tell the whole story, or representing the powerful. If you do not tow the line you will be lablled and defamed with impunity.

I cannot understand how helping people has become wrong. We are living in a screwed up (backward, self-interested, conflicting) system that promotes sickness in the name of health.

Why, Why, Why!!

Hang in there Gal.

Abstract
Context: Violence towards others is a seldom-studied adverse drug event and an atypical one because the risk of injury
extends to others.
Objective: To identify the primary suspects in adverse drug event reports describing thoughts or acts of violence towards
others, and assess the strength of the association.
Methodology: From the Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) data, we extracted all
serious adverse event reports for drugs with 200 or more cases received from 2004 through September 2009. We identified
any case report indicating homicide, homicidal ideation, physical assault, physical abuse or violence related symptoms.
Main Outcome Measures: Disproportionality in reporting was defined as a) 5 or more violence case reports, b) at least twice
the number of reports expected given the volume of overall reports for that drug, c) a x2 statistic indicating the violence
cases were unlikely to have occurred by chance (p,0.01).
Results: We identified 1527 cases of violence disproportionally reported for 31 drugs. Primary suspect drugs included
varenicline (an aid to smoking cessation), 11 antidepressants, 6 sedative/hypnotics and 3 drugs for attention deficit
hyperactivity disorder. The evidence of an association was weaker and mixed for antipsychotic drugs and absent for all but 1
anticonvulsant/mood stabilizer. Two or fewer violence cases were reported for 435/484 (84.7%) of all evaluable drugs
suggesting that an association with this adverse event is unlikely for these drugs.
Conclusions: Acts of violence towards others are a genuine and serious adverse drug event associated with a relatively
small group of drugs. Varenicline, which increases the availability of dopamine, and antidepressants with serotonergic
effects were the most strongly and consistently implicated drugs. Prospective studies to evaluate systematically this side
effect are needed to establish the incidence, confirm differences among drugs and identify additional common features.
Citation: Moore TJ, Glenmullen J, Furberg CD (2010) Prescription Drugs Associated with Reports of Violence Towards Others. PLoS ONE 5(12): e15337.
doi:10.1371/journal.pone.0015337

This article on the Union of Concerned Scientists website may be of interest:

The White House’s Scientific Integrity Directive

On December 17, 2010, recognizing that political interference in science had become a serious problem, the White House released a Scientific Integrity Directive.

If fully implemented by federal agencies and departments, the directive could help protect government scientists from pressure by special interests, and would ensure that the government can make fully informed decisions about public health and the environment.

The directive is a response from White House Science Advisor John Holdren to a March 2009 presidential memorandum which outlined broad scientific integrity principles for the executive branch.

For years, interference from politicians and government officials has prevented government scientists from doing their jobs, and has led to flawed policy decisions on numerous issues, from prescription drug safety to childhood lead poisoning. In a recent survey conducted by the Union of Concerned Scientists (UCS), hundreds of government food safety scientists and inspectors reported political and industry pressure to soften their scientific findings.

Link: http://www.ucsusa.org/scientific_integrity/solutions/big_picture_solutions/SI-directive.htm

My son died because of these nasty ugly disgusting drugs. I wish I had known Dr. Lucire the moment I found out heath service doctors were lying to my son and forcing him to take these pharmaceutical products against his will.
For three years they had been drug treating my son with antipsychotics and polypharmacy without my knowledge. When they absolutely had to tell me because he was admitted to a clinic involuntarily, a psychiatrist told me my son has a brain imbalance and our drugs will correct that. Two years later that same psychiatrist told me the same lies as if I had learned nothing in the intervening years.
After first admission he was placed under community treatment order and was force drugged thereafter. Resentment, shame and akathisic violence erupted later upon that same doctor who then had him jailed and heavily drugged for six months after which he was transferred back to the same clinic with a new treater who continued drugging him until they released him alone without telling anyone. The next day he tried to commit suicide but they let him out again; incredibly again they released him without notifying anyone. Two days later he had jumped to his death.
The coroner refused to investigate; according to the DoHA coroners are supposed to investigate these sorts of events are they not?
Had I known Dr. Yolande Lucire two years before my son jumped he would be alive today.
However you look at these drugs they do irreparable damage, starting with manipulation of drug trials results. If they work at all they are unsafe with a long list of unwanted and very undesirable side effects, some of which in some people induce certifiable psychoses and with continuing and inappropriate treatment induce suicide or worse.
Has anything been done about that TGA Report of their Psychiatric Drug Safety Expert Advisory Panel; Dr. Lucire was instrumental in providing data for that. When is something to be done now that we all know these drugs kill patients?
Interesting link to pharmacogenetics, law and personalized medicine: http://documents.scribd.com/docs/z77owganjgexi2xra4d.pdf

Heather ASHTON DM FRCP, Emeritus Professor of Clinical Psychopharmacology, Newcastle University, UK.

Video: http://vimeo.com/15985077

"Prescribing Influences in Mental Health"
About how the pharmaceutical industry influences choice of treatment.

(2008 APRIL charity Adverse Psychiatric Side Effects Conference)

UK CORONER NIGEL MEADOWS

Part time President of the Mental Health Review Tribunal, Coroners Society representative on the Forensic End Users group, member of the steering group for the National Confidential Inquiry into Suicides and Homicides by people with mental illness.

Video: http://vimeo.com/16115327

"The Rumsfeld Syndrome"

*The link in Elizabeth Hart's very interesting and informative post needs htm changing to html to find the webpage.*

Dr Ben Goldacre, author of Bad Science, columnist in The Guardian, gives a talk at the APRIL conference 2008.

"How Drug Trials Are Rigged"

Video: http://vimeo.com/15986864

Peter King's article is a must read for doctors. It does not endorse scientology or anti-psychiatry. It simply raises some critical medical issues and promotes the need for doctors to better understand the drugs they prescribe and to be more diligent when prescribing drugs for any illness, disorder or disease. This seems to be particularly true when doctors treat mental illnesses with psychotropic drugs, where ghostwriting and other unethical practices seem to be most prevalent.

There is unquestionably growing evidence that big pharmaceutical companies (Big Pharma) care much more about big profits than citizen health. The greed of Big Pharma is killing people. A January 2011 article in Vanity Fair even describes how clinical trials are being conducted in less privileged countries (than the U.S.) where there is little oversight from the F.D.A.

My tragic personal catastrophic wake up call about the dangers of prescription drugs was in July 2004. After being on the SSRI Paxil for less than 3 weeks, I became severely psychotic and killed my 11-year-old son Ian. My doctor did not tell me any of the side effects that I might experience when I first started taking Paxil. You can read about my family tragedy at www.davidcarmichael.com or watch http://www.youtube.com/watch?v=ev3VbZMfCOg

CONGRATULATIONS to Dr. Lucire and the other world leaders mentioned in the article for having the courage to raise such important medical ethical issues and for speaking out about, not against, psychotropic drugs.

If Canadian doctors had a better understanding of these issues, Ian, who would have turned 18 just over a week ago (December 14), would still be alive

The case of • States v. Palazzo, M.D., 558 F.3d 400, 2009 U.S. App. (5th Cir. La., 2009). This case demonstrates how the acquisition of capital has taken over the maintenance of good health.

The idea that Australia is ignoring international health warnings, or to say that Australia is extremely "slow" to react is now becoming more and more apparent. The issue of persons self harming is not new.
Judge Ambrose in (Cassidy) noted upon evidence adduced at trial with respect to a study with a low error rate, that “the incidence of persons on Prozac deliberately self-harming were several times more than people not on antidepressants”.

The next question we should ask is, if political will is slight will (Big Pharma) take advantage of this power vacuum. The regulatory arm of politics in Australia is controlled by the TGA. Are they doing enough to protect people, or are they protecting 'the Bottom line' or "Making a Killing"?

This is not about targeting agencies or groups, what it is about is expanding our knowledge of products that are demonstrating that they are harmful. Confidence in a system is undermined, that is,It is hard to beleive a politician when they argue for the safety of the community when on the other side they allow the actions of Big Pharma to compromise the safety and welfare of all people.

Perhaps current society is facing a number issues similar to those found in ancient societies. It took many years for the Hysteria surrounding witch hunts to subside, the reason was the rulers refused to beleive in "Reason" and "Evidence".

What could be occurring here is Big Pharma may be creating the problem
of Mad and Bad under t he guise of "Health". This guise is promoted by others as the 'pill to cure all ills.' Similar to the historic travelling sales men selling hair tonics and magic formulas to a gullible public.

1.Without Dr. Lucire I would still be having regular hospitalization.
2.A respected psychaitist tried twice to withdraw me from the SSRI's
with very unpleasant results. He referred me to Dr. Lucire for
assessment.
3.Dr. Lucire was never against drugs in general because she used others in the process of my withdrawal. Her original assessment was not walk in the room, you are on SSRI and need no medication. It was a tedious one and half hour assessment.
4. Dr. Lucire said that if after withdrawing she believed I needed medication there are safer drugs that we can try.
5. The SSRI side effects affected not only me but my whole family. Where are the doctors who can see the amazing improvement in me who are frightened to speak up.
6.Dr. Lucire expertise in the field of withdrawal is invaluable.

Psychiatry does not want to look at its problems, so it has to kill the messenger. All this can be resolved if we understand individual genetic differences in metabolism, the solution is on our doorstep. We have data.
Archives of General Psychiatry. 2007;64(10):1123-113.
A Systematic Review of Mortality in Schizophrenia Is the Differential Mortality Gap Worsening Over Time? Sukanta Saha, MSc, MCN; David Chant, PhD; John McGrath, MD, PhD, FRANZCP
Context: Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
Objective: To explore the distribution of standardized mortality ratios (SMRs) for people with schizophrenia.
Data Sources: Broad search terms were used in MEDLINE, PsychINFO, Web of Science, and Google Scholar to identify all studies that investigated mortality in schizophrenia, published between January 1, 1980, and January 31, 2006. References were also identified from review articles, reference lists, and communication with authors.
Study Selection: Population-based studies that reported primary data on deaths in people with schizophrenia.
Data Extraction: Operationalized criteria were used to extract key study features and mortality data.
Data Synthesis: We examined the distribution of Sirs and pooled selected estimates using random-effects meta-analysis. We identified 37 articles drawn from 25 different nations. The median SMR for all persons for all-cause mortality was 2.58 (10%-90% quantile, 1.18 - 5.76), with a corresponding random-effects pooled SMR of 2.50 (95% confidence interval, 2.18 - 2.43). No sex difference was detected.
Suicide was associated with the highest SMR (12.86); however, most of the major causes-of death categories were found to be elevated in people with schizophrenia. The SMRs for all-cause mortality have increased during recent decades (P=. 03).
Conclusions: With respect to mortality, a substantial gap exists between the health of people with schizophrenia and the general community. This differential mortality gap has worsened in recent decades. In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention

Psyciatry has problems. Those who read journals know about them.

BRITISH JOURNAL OF PSYCHIATRY (2006), 188, 122 - 127
Schizophrenia, neuroleptic medication and mortality. Matti Joukamaa, Markku Heliovaara, Paul Knekt, Helio Vaara, Arpo Aromaa, Raimo Raitasalo and Ville Lehtinen

Background There is an excess of death from natural causes among people with schizophrenia.

Aims: Schizophrenia and its treatment with neuroleptics were studied for their prediction of mortality in a representative population sample of 7217 Finns aged 530 years.

Method: A comprehensive health examination was carried out at baseline. Schizophrenia was determined using the Present State Examination and previous medical records.

Results: During a 17-year follow-up, 39 of the 99 people with schizophrenia died. Adjusted for age and gender, the relative Mortality risk between those with schizophrenia and others was 2.84 (95% CI 2.06^3.90), and was 2.25 (95%CI 1.61-3.15) after further adjusting for somatic diseases, blood pressure, cholesterol, body mass index, smoking, exercise, alcohol intake and education. The number of neuroleptics used at the time of the baseline survey showed a graded relation to mortality. Adjusted for age, gender, somatic diseases and other potential risk factors for premature death, the relative risk was 2.50 (95% CI1.46-4.30) per increment of one neuroleptic.

Conclusions: There is an urgent need to ascertain whether the high mortality in schizophrenia is attributable to the disorder itself or the antipsychotic medication

Why are Australian regulators and doctors suckers for this fraud? Partly, at least, because they kill the messenger.

Google Reverse Gullibility.

Why does Australalia not have a False Claims a ACT and whistleblower rewards instead of whistleblower denigration? Are we so arrogant the we think we know everything? And that there is nothing we do not know? Or cannot learn?
BMJ 2010; 341:c7360 doi: 10.1136/bmj.c7360 (Published 21 December 2010)

News
US drug companies paid $15bn fines for criminal and civil violations over the past five years
Janice Hopkins Tanne

Illegal marketing activities by drug companies have risen over the past five years, leading to major penalties when companies forced to settle with the federal and state governments, says Public Citizen, an independent US watchdog organisation. It has called the drug industry “the biggest defrauder of the federal government.”

Although reports of drug companies’ misdeeds have been reported before, Public Citizen’s new report summarises the situation.

Industry spokespeople said that the problems were behind them and that the industry had put stricter guidelines in place.

Sidney Wolfe, director of Public Citizen’s health research group, told the BMJ that in the past five years the drug industry moved ahead of the defence industry and all other industry sectors in the amount of civil penalties for fraud under the False Claims Act against the federal government. The report said that of 165 drug company settlements comprising $19.8bn (£12.8bn; €15bn) in penalties over the past 20 years, 73% …

Professor MUNIR PIRMOHAMED MB ChB PhD FRCP,
Personal Chair in Clinical Pharmacology at The University of Liverpool, NHS Chair of Pharmacogenetics, main area of research: pharmacogenetics and drug safety.

Prof Pirmohamed gives a talk at the 2008 APRIL Conference on

"The pressing need for pharmacogenetics"
VIDEO: http://vimeo.com/15987982

The important relationship between genetic predisposition and drug response is an important issue that Dr Yolande Lucire has written about.

ANDREW HERXHEIMER, clinical pharmacologist, Emeritus Fellow of the UK Cochrane Centre Oxford, co-author of first published critical appraisal of ADR reports, co-founder of dipex.org leads the

"Talk & Panel Discussion" with Professor David Healy and several others, chaired by Dr Joanna Moncreiff.

Video: http://vimeo.com/16363571

______________________________________________________________________

Some so-called scientists in Australia who should know better are behaving disgracefully both towards Dr Lucire and towards Australians at risk of harm from the various failures in the system outlined in Peter King's important article and in many of these messages.

The attempts to silence her seem somewhat reminiscent of the practices of the old Soviet Union. Things are changing across the world and will continue to change regardless.

These changes WILL reach Australia eventually, whether it is seen to have taken an active part to work towards improving the flaws inherent in these issues or, more damningly, it is seen to have worked against improvement and patient safety.

It is time for Australia to wake up and put science, research and patient safety FIRST - something that the good and very brave Dr Yolande Lucire has been doing for quite some time.

Wouldn't it be a wonderful gift to the Australian people if other concerned scientists used the new year to take a courageous stand alongside Dr Lucire to help put science back into medicines?

A group can achieve far more change for the better in 2011 than one person alone.

When a few people have the courage to speak out, others will eventually become brave enough to follow, just as they are doing in other parts of the world.

______________________

'Above All, Do No Harm'.

The National Forum Comment (2) [SENT] [Posted on The National Forum ByTheWay29]
Friday, December 24, 2010
The pressing need for Pharmacogenetics! My son was unable to metabolize drugs health services forced him to take. How do I know?
I had his DNA and requested a CYP P-450 test. This test revealed he was unable to metabolize most all their pharmaceutical products. These drugs accumulated in his system to overdose, taking him beyond therapy; he exhibited psychoses because he did not possess the cytochrome energy to trigger metabolizm. This overdosing caused iatrogenic akathisia and he never got better, only worse because of the forced drugging, progressing from lethargy and zombie-like loss of concentration to thinking of suicide because they would not stop drugging him.
They then mis-labeled him schizophrenic; after a year or so of their coerced forced drugging with debilitating so-called antipsychotics; with neuroleptics, their chemical lobotomy drugs. They were so incompetent they wanted me to believe they were wondering whether he was bi-polar! Whatever excuse they could plausibly come up with to maintain their deceit.
My son presented with adverse drug reaction symptoms and they well knew it, so why was he drug treated falsely as schizophrenic with neuroleptics when he was never schizophrenic? Had he been CYP P-450 tested initially they would never have gotten away with this false diagnosis fraud. They didn’t even bother giving him a few good doses of dextromethorphan to find out.
This is why Pharmacogenetics is such a pressing issue.
The commissioned Deloitte report December 2008, “Realizing the Potential of Pharmacogenetics”, http://www.achr.com.au/pdfs/PharmacogenomicsReportFINALDec2008.pdf recommends pharmacogenetics be introduced to Australian health services within ten years. Search find: ten years. Page seventeen says introduction of PGx will save $1.6 billion per annum in health costs due to avoiding adverse drug reactions; it does not stop with just psychiatric drugs.
In the meantime mental health services leave patients to overdose, to commit suicide while coroners refuse to investigate. Thank you Dr. Yolande Lucire and Dr. Zappp I agree because I’ve read some of the books and seen most of the videos thanks to respected friends.

To ByTheWay29 - my 4th therefore final post for the next 24 hours.

Thank you for the link, but is there an error in the url or a problem with the page at the moment? I cannot access it but will try again later anyway.

I have to clear one point up - I am definitely NOT a doctor. I've posted links to videos of doctors speaking in a conference and that may have given the impression that I too must be a doctor, but that wasn't intended.

Doctor Lucire is one very good, scientific, courageous doctor though and if those trying to silence her had the courage and the decency to do what is right, they'd be making a difference by listening, debating, researching and acting in the interest of patient safety.

Queensland, Australia.
Why does this "unclear" issue not reach practicing psychiatrists? Why is death rate associated with psychiatric medications found in their clinical trials not examined, improved or targeted? The resolution lies in better diagnosis and the intelligent application of pharmacogenomics.
Why does this not reach practicing psychiatrists and conferences? Because they are funded by drug companies.

See the Healy et al paper above: Whom are we kidding? Suicide has increased 20 fold over the 1930s cohort with increases in services and new but not better drugs.
Archives of General Psychiatry. 2007;64(10):1123-1131
A Systematic Review of Mortality (SMR) in Schizophrenia: Is the Differential Mortality Gap Worsening Over Time? Sukanta, S. et al.

Objective: To explore the distribution of standardized mortality ratios (SMRs) for people with schizophrenia
Context: Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
Data Sources: Broad search terms were used to identify studies that investigated mortality in schizophrenia, published between January 1, 1980, and January 31, 2006.

Study Selection: Population-based studies that reported primary data on deaths in people with schizophrenia.
Data Extraction: Operationalized criteria were used to extract key study features and mortality data.
Data Synthesis: The median SMR for all persons for all-cause mortality was 2.58 ... No sex difference as detected.

Suicide was associated with the highest SMR (12.86);

... most of the major causes-of-death categories were found to be elevated in people with schizophrenia.

The SMRs for all-cause mortality have increased during recent decades (P=.03). (Unclear?)

Conclusions: With respect to mortality, a substantial gap exists between the health of people with schizophrenia and the general community.
This differential mortality gap has worsened in recent decades.
In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention

It is so easy to see the substance and factual content for Dr. Lucire’s whistle blowing that it reminds me of the Emperor’s New Clothes fable. What concerns me more is the denial and/or complicity of those that see, and do not act.

Another concern, are the repercussions of the restrictions placed upon Dr. Lucire.. . Dr. Lucire has unequivocally saved many people’s lives….in more ways than one. She has given of herself to her patients with unrivalled integrity and honesty. Her expertise untarnished by corrupt medical practices and peer pressure. Dr Lucire is an unusually honest and brave human who challenged a corrupt and self-centered industry. Restricting access to Dr. Lucire’s expertise and integrity will cause harm in itself.

What makes the hurt so much greater are articles like “drug induced akathisia” in Dec.2010 Australian Prescriber”, which do not acknowledge any of Dr. Lucire’s contribution to the raising of awareness of the issue. Dr. Lucire, after exposing the issue continues to be vilified while more eminent individuals and media start circulating the subject matter, and claim the credit .

And though in the end the public do see the emperor has no clothes, Dr. Lucire, whom first called the fact suffers damaging slander and disparagement which is never fully addressed. . Although our world may become a better place through this process, it is a superficial one, and the burning up of such an honest and courageous person is a horrendous and primitive by-product of change.

“Evil occurs because good people do nothing”.

Amazingly...more than 250 psychiatrists have been involved in the treatment of my son... Yet, only one psychiatrist ever asked him what effect these drug's were having upon his well-being. That psychiatrist was Dr.Yolande Lucire...and Dr.Lucire was'nt even treating him...

It appears that psychiatrists have become the pimps for the big PharMa...pushing the drugs. Was it Voltaire who stated that "...Doctors prescribe drugs of which they know little for patients of whom they know even less?"

Perhaps its time that those psychiatrists took note of he warnings of by Dr.Lucire..

I’m aware from the experience of family members that some people indeed get worse, not better on prescribed antipsychotic drugs and that doctors are loathe to recognise or acknowledge this. The fact that there is much literature on genetic causation as to why some do not respond and indeed become extremely toxic, does not seem to have reached the medical profession in Australia.
Why would this be?

Yes to an extent we live a global village, one that is becoming increasingly combined temporally and spatially using the concept of globalisation. The objective (they say) was to transcend local and international boundries linking trade, communications, legal systems, finance etc...
Despite these principles being implimented, Australia remains in a Dark hole, perceivably sealed off from the outside world, ignorant to progressive scientific reasoning. This scientific reasoing is presenting an excellent prima facie case for further examination and research in the Psychopharmacology and Pharmacogenetics arena. But as we can see, the health of the community is one that is best applied by spewing out Mantra's in the media rather than "real" and practical progression, one that is based upon scientific evidence and Not evidence that was paid for in what amounts to others peoples "ill-health".

**(Continued from Last Post)**

I am amazed that the level of ignorance within our (Medical and reglatory) establishments is anything but progressive in terms of protecting people. Yes they are protectionists, but only of profits, not health.
The political mantra's about health care seemingly and pragmatically amount to nothing more than comments designed to appease the masses. They have little or no scientific reasoning, rather allot of money to push and peddle the mass media machine into marketing products, no matter how harmful. Perhaps this political correctness of labelling all people with disease is nothing more than the most polite form of tyrany we have?
Indeed, It is reminiscent of the medievil raiders whose rhyming motto was to "rape, pillage, burn the village".
The next question is, do we live in an age of reason where human life is worth more than a political speech or hypnotically repititive mantra, or do we reside in a medievil village where the desire is "rape, pillage, burn the village".
One thngs for sure, when people like Dr Lucire are stigmatised for their exposure of an industry that is designed around making profit, not healthy people, we can only wonder what happened to reason, our reglatory system and human rights. The message i see is, if you help people aas Dr Lucire did, you are stigmatised and defamed. But if you poison people on mass, you are a hero.
With no surprise, I prefer to support Dr Lucire's sincere adherence to her duty of helping, not hurting.

FDA Patient Safety News (March 2007)

Genetic Testing to Help Reduce Chemotherapy Toxicity

Short Video: http://video.google.com/videoplay?docid=7866406980637597258#
.

Links to FDA Patient Safety News article at
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/transcript.cfm?show=64#6

"Genetic Testing to Help Reduce Chemotherapy Toxicity

Everyone responds differently to medicines. The dose of a drug that cures one person can be ineffective-or even toxic-in someone else. Although many non-genetic factors play a role in how an individual patient responds to a particular drug treatment, many differences in drug response come from genetic variation. Individualizing a drug's dose based on pharmacogenomic information can help a patient get the most benefit from a drug while minimizing side effects.

Take the example of treating colorectal cancer with a chemotherapy regimen that includes Camptosar (irinotecan). A gene, called UGT1A1, produces an enzyme that metabolizes Camptosar. Variations in this gene can influence a patient's ability to break down the drug.

About 10 percent of the North American population has a variation of the UGT1A1 gene that reduces their ability to metabolize Camptosar, leading to high blood levels of the drug and a higher risk of toxic side effects. If these patients are given standard doses of Camptosar, about half will develop severe neutropenia, which can be fatal.

A test, called the Invader UGT1A1 Molecular Assay, can identify whether a patient has the genetic variant affecting the metabolism of Camptosar and thus would be at higher risk for developing severe neutropenia. The drug label says to consider lowering the starting dose of the Camptosar for those patients found to be high risk.

Additional Information:

Table of Valid Genomic Biomarkers in the Context of Approved Drug Labels. October 27, 2006.
FDA Clears Genetic Test That Advances Personalized Medicine. August 22, 2005.
National Institute of General Medical Sciences. Pharmacogenetics Fact Sheet. May 2006"

It is quite obvious that Dr Lucire is scientifically and absolutely correct in her concern about genetic variation and drug response.

This 52 minute video dated February 2006, nearly 5 years ago, is called

"Opportunities For Pharmacogenomics and Personalized Medicine"

VIDEO: http://video.google.com/videoplay?docid=5976890974902036286#

.

Professor Russ B Altman is "director of the Center for Biomedical Computation at Stanford University and is director of the biomedical informatics training program. He is also the principal investigator of a project, PharmGKB, which is an online database of genetic and phenotype information from people who have participated in research studies at various medical centers participating in the PGRN.

ABSTRACT Pharmacogenomics is the study of how variation in human genes leads to variation in drug response. One of the major promises of the genome project was to improve medical outcomes for patients by using knowledge of their genetic background.

The PharmGKB (Pharmacogenomics & Pharmacogenetics Knowledge Base, http:// www.pharmgkb.org/) is an NIH-funded resource at Stanford University charged with supporting the research community in pharmacogenomics, by storing both genetic variation information and drug-response information, building tools to help scientists visualize and analyze the data, curating the pharmacogenomics scientific literature (both manually and through text processing algorithms), representing pathways of genes that work together to affect drug response, and providing expert annotation of current pharmacogenomic knowledge"

Dr. Magnus Ingelman-Sundberg at the April 10, 2009 Conference at University of California, San Diego, presents his recent paper on:

"Pharmacogenomic biomarkers for prediction of "severe adverse drug reactions"

16 mins VIDEO: http://www.scivee.tv/node/10761
.

Some of Professor Ingelman-Sundberg's publications, such as
"The human genome project and novel aspects of cytochrome P450 research
Magnus Ingelman Sundberg
Division of Molecular Toxicology, IMM, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Toxicol Appl Pharmacol 207:52-6"

can be accessed at:
http://www.labome.org/expert/sweden/karolinska/ingelman-sundberg/magnus-ingelman-sundberg-384718.html

To quote Jonathan Emord in discussion of his book, “The Rise of Tyranny”:
In my book The Rise of Tyranny I explain that FDA has become a captive of the drug industry and that repeatedly its Commissioner approves drugs over the safety objections of FDA medical reviewers. Dr. David Graham, FDA’s Associate Director of the Office of Drug Safety, has severely criticized his own agency for repeatedly approving unsafe drugs. “FDA is inherently biased in favor of the pharmaceutical industry,” said Dr. Graham. “It views industry as its client whose interests it must represent and advance. It views its primary mission as approving as many drugs as it can, regardless of whether the drugs are safe or needed.” Indeed, FDA performs no drug safety testing of drugs but relies entirely on the drug sponsor’s own testing. If the drug sponsor, who has an obvious economic interest in either not revealing or downplaying risks, fails to bring all identified risks to the agency’s attention, the agency presumes those risks de minimis or non-existent. Perhaps as many as 15% to 20% of all drugs on the market today are ones that carry serious side effects, including heart attack, stroke, neurological disorders, kidney failure, liver failure, and death. http://www.newswithviews.com/Emord/jonathan169.htm

To quote Jonathan Emord from his latest book, “Global Censorship of Health Information”, otherwise known as, “The Politics of Controlling Therapeutic Information to Protect State-Sponsored Drug Monopolies”, from page 30, second paragraph,
“By forbidding all actual and potential competitors from the market, governments worldwide ensure that companies holding a government license or grant of approval to market a drug enjoy total exclusivity and can set literally any price the market will bear for the approved drug. When a drug is approved for a disease, therefore, it is possible for a drug company to price each unit at hundreds or thousands or even tens of thousands of times the cost of making it, at the price calculated to achieve the highest profit.”
When those responsible for separation of powers in the legislature, the executive and the judiciary merge under an all powerful bureaucratic oligarchy having devolved into utter corruption, does this mean they just don’t give a damn about patient safety? Is this why Pharmacogenetics and Cytochrome P-450 Testing is facing such unwarranted delay in wholesale introduction into Australian Health Services?
Is this profit motive the reason why 25% of US children are now on chronic prescription medications? http://www.naturalnews.com/030879_children_drugs.html Is it true all they care about is these massive profits and to hell with patient safety? Is it just deceit and greed?
Jonathan Emord: http://www.google.com.au/#hl=en&source=hp&biw=941&bih=770&q=jonathan+emord&aq=f&aqi=g1g-v9&aql=&oq=&gs_rfai=&fp=19436dfea8718869

It is becoming clearer that the abhorent abuse of these medications is worth an examination. But then again, who will examine them? Its like arguing to Ceasar about Ceasar. But then again, what if Ceasar is being lied to as well? What if the Taxpayer is funding a massive fraud?

I recenetly read an article based upon the Qui Tam Legislation in the USA. Please read this, as it provides the people being (maimed and possibly murdered) with a remedy.

It is time that Politicians began to take notice of the people.
I have added the link below.

Please let me know if you think this would be a good idea in Australia?

http://www.cla.asn.au/0805/index.php/articles/2010/qui-tam-do-we-need#more9747

Its sad to see that we live under a cleverly designed semblance of moral and ethical reality. Its Kindergarten on a global scale.

May the new year bring some normalacy to this designed insanity.

Further to my Previous post I need to add this.

Dr. Lucire’s submission to the current Senate Suicide Inquiry is referenced to leading journals and the NSW Department of Health.

http://www.aph.gov.au/Senate/committee/clac_ctte/suicide/submissions/sub243.pdf

43 homicides and nearly 1,000 suicides under mental health care in NSW since 1992.

Calculate Australian deaths by looking at NSW, which has one third of the population. That is not to say the drugs are no good, they are being used badly and for conditions they cannot relieve.

Mental Health care is where these new drugs are being given in various combinations with disastrous outcomes.

If you want to know why someone died under NSW Mental Health care, it costs $30,000 to get a coroner to look.

And if the coroner finds negligence, he bills you, not the Department of Health. You still have to sue to get it back, and that costs thousands more dollars.

Deaths from adverse drug reactions/interactions (ADRs) are among the four big killers: cancer, heart attacks, and strokes. They need the same level of research funding as the big ones as they fill hospital beds and generate similar costs.

ADRs are being swept under the carpet.

http://psychrights.org/states/Alaska/CaseOne/30-Day/ExhibitD-Olanzapine.ht

Continuation From Previous Post **(Because word limit reached)**

From Allen Jones whistleblower and Robert Whitaker, Mad In America.

FDA data indicates that one of every 145 patients enrolled in clinical trials of the schizophrenia drugs (Risperdal, Zyprexa and Seroquel) died of side effects. In some trials, 22% of participants were hospitalized with severe adverse reactions.

http://psychrights.org/index.htm.

And those public servants who licensed these drugs for Australian use, subsidised were not told they were most people could not take them even for six weeks, nor why they could not take them, (serious adverse drug reactions) and were given no information at all about deaths and suicides.

All those who licensed these drugs, prescribed and took them are also victims of this fraud.

IN USA defrauded states and users have legal retribution. Why not here?

It is time to face up that Australia, as well as USA, has been duped by the biggest fraud-mongers on the planet. Big Pharma.

David Healy summarised these frauds in this paper in 2006. http://www.tasmantimes.com.au/manufacturing-consensus

Maybe this situation (and others like it) has arisen due to modern day cases of 'Reverse Gullibility' described in the link below by Robert H Riffenburgh, PhD. The abstract describes why Louis Pasteur, Ignaz Semmelweis and others were disbelieved by the medical profession generally at the time and ends:

"To be truly professional, let us believe our evidence rather than our biases and not suffer from reverse gullibility."

http://archotol.ama-assn.org/cgi/content/abstract/122/6/600

All praise be to brave doctors like Dr Yola Lucire who dare to tell us the truth.
Many of those poisoned by pesticides and related chemicals in the UK are both silenced and made to suffer worsening health conditions by the inappropriate prescription of the contraindicated psychiatric and cardio-respiratory drugs.
Pesticides such as the organophosphorus group are normally highly lipophilic and can therefore easily cross the blood brain barrier where they cause damage to the brain and its cognitive function impairing thought processes and inducing psychiatric effects. By nature many of the antipsychotics have similar properties and target the same areas of the brain.
This is a case of profit maximisation. Induce the symptoms and sell the "cures", which induce further symptoms.
Who will fight against the "experts" when in a drugged stupor...?

Breggin Peter R., Ethical Human Psychology and Psychiatry, Volume 8, Number 3, Fall/Winter 2006

Intoxication Anosognosia: The Spellbinding Effect of Psychiatric Drugs Ithaca, NY

Why do so many individuals persist in taking psychoactive substances, including psychiatric drugs, after adverse mental and behavioral effects have become severe and even disabling?

The author has previously proposed the brain, disabling principle of psychiatric treatment that all somatic psychiatric treatments impair the function of the brain and mind. Intoxication anosognosia (medication spellbinding) is an expression of this drug-induced mental disability.

Intoxication anosognosia causes the victim to underestimate the degree of drug, induced mental impairment, to deny the harmful role that the drug plays in the person's altered state, and in many cases compel the individual to mistakenly believe that he or she is functioning better.

In the extreme, the individual displays out of character compulsively destructive behaviors, including violence toward self and others

Dr. Lucire was a great help to me through a a very difficult time. My 18 year old daughter had killed herself in a Paxil-related suicide. Yola helped me safely withdraw from Effexor & Imovane - she in Auatralia & me in Canada - over the internet. I took her advice to my GP and he fully agreed with her change in treatment.

If anyone needs to understand the essence of Dr. Lucire's work or what she is trying to do - or rather what she is trying to prevent - then GOOGLE Sara Carlin Inquest - and one can see how a drug, already known to be dangerous to youth - can have devastating effects. If there is still a doctor out there that beleives "Paroxetine [Paxil, Seroxat, Aropax] is generally well tolerated and effective for major depression in adolescents" - then he or she should probably consider ECT therapy or perhaps an atypical antipsychotic - for themselves - to help get back to reality.

Kudos for Dr. Lucire - she deserves a nobel prize for the work she does.

Nel Carlin
Oakville, Onratio
Canada

Anyone interested in how the UK treats reports concerned about adverse drug reactions would be interested in this set of videos.

feed://vimeo.com/user1816628/videos/rss

When the British Healthcare Commission received an overwhelming number of reports of persons becoming suicidal and homicidal on psychiatric (and other) medicines, it did not use peers of the prescribers, it did not defend the profession, it did not defend itself: it protected the public.

They did not use cronies, or persons likely to have the same knowledge deficits.

They did not use buddies of the doctors about whose prescribing reports had been made, nor did they ignore Product Information and Public Health Advisories in favour of using "peers" who, like the prescribers, had read none of this essential documentation.

They called relevant experts, consultant pharmacists, pharmacologists and pharmacogeneticists and started to re-educate the community. A parliamentary inquiry was called in 2005.

The role of the Medical Board of NSW, now Medical Council of NSW is protect the public and to protect the public.

This is the only way medicine gets better. It does not improve if problems internal to medical practice are routinely covered up and whistleblowers are done in.

This issue does not concern individual doctors, as the Health Care Complaints Commission seems to think (or maybe its legislation forces it to think like that.)

This problem is caused by pharmaceutical industry fraud, which affects patients, prescribers, peers and judges.

It is time to go to your members of parliament or candidates and get it fixed.

Dr. Yolande Lucire’s knowledge of akathisia-suicide and violence caused by psychiatric drugs and its relationship to diminished metabolizm genes inspired me to investigate my son’s drug-induced suicide.
He consulted mental health because he had used cannabis; he was not schizophrenic ever. He committed suicide under NSW mental health care. He was also under community treatment order force drugging. He is possibly one of the un-investigated “80-100 suicides”, but maybe not as the coroner suggested he had been like Private Kovco who had been deemed “skylarking.”
They do not even know how many or what they were taking; this is a problem, he was on huge doses, 600 mg of zuclopenthixol, this is metabolised by CYP450 2D6 and it also inhibits 2D6 metabolizm so he could not metabolize it at all and he was made toxic, suicidal and violent. He was a genotype intermediate metabolizer (2D6*1*4) turned by the drug into a phenotype poor or non-metabolizer.
He first got Zyprexa for cannabis induced hallucinations (Zyprexa is olanzapine) 10% who do not hallucinate before, hallucinate on Zyprexa (that is in Product Information); then he was given an antidepressant, Luvox (fluvoxamine) on top, even though this drug combination is warned about in Product Information.
There was no informed consent.
He got worse, more violent and more suicidal. He was not like that before the psychiatric drugs.
Are they familiar with http://ssristories.com/ ?

Continued from preceding posting:

When my son attacked his doctor, they sent him to prison where he was injected with 400 mg of Clopixol (zuclopenthixol), metabolized by 2D6 which he lacked. This is four times maximum dosage and double with his genes. Its half-life is 19 days, so toxicity is inevitable even in normal metabolizers if given every 14 days.
He was force injected on community treatment order, signed by the same magistrate who conducted or who rather refused to conduct, an inquiry into his suicide death.
He tried to kill himself and when brought back to the hospital was so suicidal they re-diagnosed him as having “personality disorder”.
He killed himself within two days, before his next scheduled forced high dosage depot injection of zuclopenthixol.
The Medical Board of NSW and a Minister of the State Parliament both told me this was “standard psychiatric treatment.” Even after I had advised of his genetic problem; still it just goes over their heads.
The State Coroner and the Judicial Commission both told me that their magistrate did not have a conflict of interest.
Do Australians understand conflict of interest?
Can a magistrate investigate suicides caused by drugs he ordered to be enforced?
This is what the Soviets did to dissidents to torture them in the 1970s; injected huge doses of Serenace (haloperidol) and they say: look he really is mad, suicidal and violent when they were forcibly induced to develop akathisia on these drugs. This is torture?
I am not a doctor, my qualification for basic first grade reading ability is my father was a pharmacist.
The NSW medical Board and the State Government Minister are covering for each other at the Health Care Complaints Commission by defining this as “standard psychiatric treatment” even after they were told that my son was a genetically poor metabolizer (2D6*1*4) of psychiatric drugs.
This is what is wrong with Australia’s psychiatrists and lawyers.
They weave and dodge and attempt to evade responsibility for their actions while possessing no concern for patient safety yet are continually diddling the Australian Public with dangerous drugs.

ByTheWay29, thank you for sharing your loss with us. He will not be forgotten. Nor how it happened. Your courage is amazing. best wishes
Beth.

As a survivor it is difficult to know what to say.
My only input here is personal experience not science or statistics.

For the disbeliever in Yola and her works. You should have walked in my shoes for the last 25 years.

During one of my hospitalizations my husband was asked to leave when he told them you are making her worse.

His comment regarding Dr. Lucire, "Yola is a breath of fresh air in the medical profession."

An excellent article by Peter King. I do not live in Oz but the manipulation of the medical care system by pharmaceutical companies is a universal problem.
I am not a medical doctor either but it is an interesting proposal that a genetic deficiency leads to the failure to metabolize antidepressants resulting in toxic levels in the body. I'm not sure that these drugs would be any less dangerous if one could metabolize them because they have so many other side-effects besides akathisia.
I became suicidal right after the first time I was prescribed antidepressants but it wasn't until I stopped taking them on my own volition against my psychiatrist's advice that I stopped being suicidal.
Dr. Yolanda Lucire is a heroine and we need more doctors like her.

My member of parliament listened politely to my history and the healing taking place and received relevant documentation sometime ago.
Like the NSW Medical Board it fell on deaf ears.

Dr. Lucire did not discharge me. Nor did I choose to cease consultation with her. The NSW Medical Board decided that for us.

Where are the other ex-patients?
Are they busy rebuilding their lives and making up for lost time?
Do they not have google alert for Dr. Lucire hoping to see a Nobel Prize?

No, perhaps they are intimidated by the NSW Health Care Complaints Commission. One can only assume they received the same letter followed by the lengthy interegating phone call.

Will the HCCC view these posts as a misdemeanor as Dr. Lucire is here also?

After the horrors of being psychotic on prescription drugs they will not frighten me...

Dear Bob47,

Your comment is typical.

It is not an 'interesting proposal' the genetic mutations associated with poorly metabolising genes are linked to side effects. It is well established that side effects are related to blood levels. If they recognised them, psychiatrists decreased the dose when side effects appeared. My colleagues recognise dyskinesia, spasms, but fail to recognise akathisia. The relevant genetic information in contained in product information. Inability to metabolise leads to drug toxicity and side effects.

Google safety pharmacogenetics. This information had not yet reached the regulators of the antipodes but is in few centres of excellence.

Drug reps go around telling doctors that suicidality is not a side effect and that Dr. Lucire has lost her mind.

The only original finding attributable to me is that medication side effects fill hospital beds and increase demand and costs by 4% per year. They include bleeding, strokes, cognitive impairments, organic personality disorder with borderline features, akathisia, suicdality, violence and medication induced hallucinations. over 100 tested show that are getting more than they can metabolise or have mutations and cannot metabolise single doses.

Side effects are blamed by the drug companies on "the disease" so doctors give more drugs. You will see 'hostility' (homicidal thoughts) behavioural dyscontrol in jargon, behaviours uncharacteristic of the person.

From DSM IV about akathisia so you possibly did have it, as it is the condition that leads to suicidal thinking.

Associated Features of neuroleptic and SSRI-induced akathisia

... subjective complaints of restlessness...
The subjective distress resulting from akathisia is significant and can lead to noncompliance with neuroleptic treatment. Akathisia may be associated with dysphoria, irritability, aggression or suicide attempts. Worsening of psychotic symptoms or behavioural dyscontrol may lead to an increase in neuroleptic medication dose, which may exacerbate the problem. Akathisia can develop very rapidly after initiating or increasing neuroleptic medication.

The development of akathisia appears to be dose dependent.

Acute akathisia tends to persist for as long as neuroleptic medications are continued, although the intensity may fluctuate over time. The prevalence of akathisia among individuals receiving neuroleptic medication has varied widely (20%-75%)

Dear Yola:
I agree with everything you are saying. I'm sorry if you inferred that I didn't believe you about poor metabolism being the reason some people are affected more than others by antidepressants and anti-psychotics.
I have no doubt that I had akathisia from being overdosed with both antidepressants and antipsychotics. I am disappointed that my doctor never informed me about it and I only discovered it on my own by chance.
Some of the other undesirable side-effects which were debilitating for me were sexual dysfunction and inability to sleep. It only made me more depressed.
Thank goodness I was able to take myself off these drugs after taking them for almost 3 years without actually having completed suicide.
cheers,
bob47

I believe that genetic metabolism is absolutely a factor in ADRs, but I don't understand it very well. Does that mean that a drug/chemical is only toxic to people who cannot metabolize it, but that it doesn't have any toxicity to others? Is it safe for anyone that can metabolize it, ie, it isn't toxic generally?

How far away is a drug that can cause sometimes fatal ADRs to anyone who cannot metabolize it, to a substance like arsenic or cyanide that presumably is toxic to anyone/everyone. Is cyanide only toxic because nobody has the enzymes that can metabolize it?

The whole issue of the line between toxicity and genetic predisposition puzzles me a little in that way. Can anyone explain?

How do we get the whistleblower out of coventry?

November 17, 2008

FDA Finds Zyprexa Has Killed 3,400 People, Worse Than Vioxx
I was reviewing an FDA staff document this morning, wherein FDA staffers recommend additional warnings for Zyprexa for pediatric cases (ie, teens) and ran across a startling statistic. According to the agency's own adverse events database summarized in the report, the controversial atypical antipsychotic has killed 3,455 people (see page 7 of the above document) between 1997 and early 2008.

Roughly half of the deaths are known to have occurred in the US while the remainder are from unidentified locations (likely a mix of US and foreign deaths).

What startles me is that last fall I reported on a study of the FDA's adverse events database in which researchers reported that Zyprexa had killed 1,005 people from 1998 to 2005, so this new accounting represents a large increase in deaths associated with the drug. Even more, according to that same study, Vioxx had killed 932 people. So why do Vioxx cases get all the media attention while Zyprexa does not? Why is Zyprexa still on the market and raking in $4 billion or so a year in sales while Vioxx is off the market?

Why on earth has this drug been marketed for casual use far beyond its initial use as an antipsychotic?

As of now, Zyprexa is not approved for use in children and teens, but Eli Lilly has an application before the FDA to gain approval for its use in teens diagnosed with schizophrenia. Amazingly, one published study of Zyprexa in teens found that in a three-week trial of the drug patients gained an average of eight pounds, which is a lot for such a short time period. That's why the FDA staff in the above document is recommending additional warnings about weight gain in pediatric populations.

(Via Pharmalot.)

Since you asked

Characterization of Metabolic Types CYP450 enzyme-mediated drug metabolism displays wide interindividual variability. Most variants result in synthesis of enzymes that are diminished or devoid of metabolic activity or result in increased activity.

Extensive Metabolizers (EM) the normal genotype—is free of inactivating polymorphisms‚ deletions‚ or duplications. In Caucasian populations‚ EM is the most common genotype. Current drug dosing recommendations typically assume that the patient is an extensive metabolizer and can tolerate a standard dose.

Poor Metabolizers (PM). These have 2 inactivating mutations, which may be in one or two genes. Severity varies among those with a PM genotype. Most lack a functional enzyme. They receive no therapeutic benefit from drugs that are activated by CYP450 metabolism. Additionally‚ deficient enzyme function may result in an inability to clear medications‚ which may lead to toxicity and serious to sometimes life threatening side effects.

Intermediate Metabolizers (IM) these individuals have 1 normal allele and 1 allele with an inactivating polymorphism. Individuals with an IM genotype demonstrate a wide range of levels of enzyme activity. Some produce sufficient functional enzyme‚ others do not. IMs are particularly susceptible to the residual functional CYP450 enzyme being totally abolished by other drugs or metabolites, if they inhibit CYP450. Individuals with an IM genotype become poor metabolizers (phenotype) in response to a “second hit” by a CYP450 inhibitor or environmental factor.

Ultra rapid Metabolizers (UM) These individuals are rare among Caucasian but psychiatrists think they are the majority, judging from how they prescribe more not less when the drug is ineffective. The have gene resulting in too fast metabolism. UM metabolizer genotypes have been found for the CYP2D6 and 2C19 (*17) enzyme. The drug may be rapidly cleared and not reach therapeutic levels so response is poor or nonexistent. However, if the first metabolite is toxic or even active and it needs a CYP450 enzyme that is already in short supply, or being used up or inhibited, toxic side effects are the outcome. UM patients are almost always non-responders to antidepressants and some other drugs. They have problems in withdrawal as blood levels change too fast.

Good to see the very important issue of cytochrome P-450 raised.
Convinced that this is DNA damage triggered by pharmaceutical, industrial and agricultural chemicals that target the mitochondria and the protein forming enzymes, of which CYP450 is an important part.
In Gulf War Syndrome and Organophosphorus poisoning cases changes are seen in the CYP450 suggesting in the former caused by exposure to toxins but in the latter explaining genetic susceptibility to the chemicals, known to damage both DNA and the mitochondria, which are also vital to cardio-respiratory function, cell reproduction and cell death.
We interfere with these vital functions at our peril.

Cindy Duehring (1996) - cytochrome P450 enzymes are critical to human metabolic function as well as the detoxification and metabolism of the majority of chemicals…. in spite of the magnitude of their significance, the typical biochemistry textbook devotes at most one page to this important enzyme system…. 2,000+ studies each year are published on some aspect of P450 research… Over 400 P450 enzymes have been identified in living systems' including plants and animals,… research indicates over 40 different P450s can be expressed in a single mammalian species. Research into cancer prevention is just one area of P450 research. Because of the P450s' role in detoxification, .. research on the manipulation of P450s for cancer prevention and/or cancer treatment has been growing considerably.

Impaired or disrupted P450 enzyme activity has widespread ramifications in the body…play a vital role in numerous biological activities, including production and metabolism of steroid hormones …and fatty acids…. P450-dependent substances are involved in neurotransmission and central nervous system metabolism, blood clotting blood flow, gastrointestinal function and activity, cardiovascular and hematological metabolism,
carbohydrate and fat metabolism, electrolyte balance arid muscle activity, pancreatic endocrine function, anti-inflammatory activities, and glucose metabolism.....
.. a person's individual P450 makeup or status, one person may be able to handle 40 times the amount of a particular chemical than another person. The person with lesser detoxification capacity would experience the toxic effects of the chemical at a level that would seem ludicrously small to the one who could handle the large amoun

The posts by Yola and RBruceUK directly above were very helpful in clarifying what I couldn't quite get the hang of. Thank you.

Currently in the news - another tragic outcome at an Australian mental hospital where a patient stabbed two nurses, one of whom died.

VIDEO and text summary: http://orange.iprime.com.au/index.php/news/prime-news/nurse-stabbed-

At http://www.smh.com.au/nsw/three-inquiries-into-fatal-hospital-stabbing-20110106-19hmr.html
it states that how "a senior nurse could be stabbed to death by one of his psychiatric patients at a mental health facility will be examined by at least three separate investigations",

also, that "across the state the association had received more reports of nurses being attacked in the workplace"

and that a month ago, after investigations regarding two suicides by patients in mental health units, Deputy State Coroner Hugh Dillon "recommended that visitors to psychiatric units be searched for dangerous items".

At http://www.theaustralian.com.au/news/nation/nurses-killing-prompts-safety-review/story-e6frg6nf-1225983245405
it says that the nurse died after being stabbed with a knife by a patient who was classified as "low risk".

Continued from last comment:

Will 'at least three inquiries' get to the bottom of things? How many inquiries will it take before the obvious is recognized?

A "low risk" patient suddenly becomes homicidal(high risk). That ought to give a clear indication that whatever drugs he was on weren't actually working for him. From that fairly obvious conclusion the rest of the science should follow.

And why is it that psychiatric wards need security staff these days, and calls are made to require visitors to be searched? This wasn't the case before the days of Prozac.

I do not understand how teams of investigating experts cannot see that there are real problems that they need to research. Easily accesible to them is the work that has already been done by others, including that done by Dr Lucire.

Why are investigations by experts continually failing to see the answers right in front of them? Is it because they do not want to see?

It's also the ignorance amongst the general practicitioners.

An eldly
man who was stable on an antidepressant(Don't know which one). His GP told him he didn't need them any more. He stopped taking the lot immediately. He spent the next three months in a pyschiatric hospital. He had seizures and was mentally very very unwell.

All, but especially, long term users of these drugs must be withdrawn very slowly under clear supervision.

I was on them for a long time and withdrawn and now never been better.
My grandchild now has a grandmother. My adult son one day said,"It's great to have a mother back".

People here in Australia are told you have depression and will require medication for life. You must never stop. Even when the side effects start appearing they change to another SRRI and then the snowball beings. As you know I am not a doctor but I don't believe depression is a life illness but a transition in a difficult part of lifes journey.

This is off the train of thought but the local GP's don't even know the word akathasia so how can they recognize it when their patients are suffering from it.

Most of the people I know here in Oz receive antidepressants from GP's not psychiatrists.

Question asked on 13 May 2010 (session 54-1) and published in Questions & Answers Paper No. 197 <http://bulletin/prod/la/lapaper.nsf/V3QnBySN/541~197/$file/197-QA-S.pdf>
.10218—PSYCHIATRIC DRUGS
Mr Daryl Maguire to the Deputy Premier, and Minister for Health—
1. Has the Minister and her predecessors been warned by individuals that suicides committed by patients and clients under mental health care could be caused by psychiatric drugs:
1. that affect persons who have a genetically determined inability to metabolise them;
2. that such persons should be recognised by their adverse medication responses?
2. How many persons have committed suicide whilst under mental health care in the years 2003 to 2008?
3. How many have committed homicide?
4. Do these figures represent a deterioration or improvement in the numbers of suicides under mental health care:
1. before 1990;
2. before 2002?

Answer—
I am advised:
1. NSW Health advises me that there has been correspondence to previous Health Ministers in relation to this issue. I have also received such correspondence. The Chief Psychiatrist in consultation with the NSW Mental Health Clinical Advisory Council is currently considering these issues.
2. According to the Mental Health Client Incident Information System, there were 937 notifications of suspected suicides of persons under mental health care that were reported to the NSW Health Department between 1 Jan 2003 and 31 Dec 2008.
3. According to the Mental Health Client Incident Information System, there were 43 notifications of suspected homicides by persons under mental health care that were reported to the NSW Health Department between 1 Jan 2003 and 31 Dec 2008.
4. It is not possible to compare the data over this time period due to the fact that different methodology was used to collate this data

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10219—SUICIDES CAUSED BY ANTIDEPRESSANTS
Mr Daryl Maguire to the Deputy Premier, and Minister for Health—
1. How many suicides have been investigated by toxicologists or geneticists, as recommended in The Pharmacogenetics Journal to which a NSW psychiatrist has contributed?
2. Has NSW Health had genetic evaluations for "ability to metabolise drugs" as is done by medical examiners and coroners in the USA and UK to distinguish between suicide caused by mental illness and suicide caused by psychiatric drugs?
3. Can the Minister provide advice from the Department of Health on the issue of antidepressant-induced akathisia suicide and homicide?
4. Is the Minister aware:
1. of the claim antidepressant drugs increase suicide;
2. this is the subject of public health advisories in all countries other than Australia and NSW?
5. Is the Minister aware that antidepressants caused about 1 in 500 users to commit suicide in clinical trials presented to the US FDA for the purposes of licensing and follow-up studies?

Answer—
I am advised:
1. Any deaths and suicides of people under the care of public mental health services are investigated by the NSW Coroner. Questions relating to the Coronial process should be directed to the NSW Attorney General.
2. NSW Health has not funded any research into 'genetic evaluations for ability to metabolise drugs'.
3. to (5) The Chief Psychiatrist in consultation with the NSW Mental Health Clinical Advisory Council is currently considering these issues.
4. I invite the Member to submit any studies or material he may have on these issues for further consideration

"2. NSW Health has not funded any research into 'genetic evaluations for ability to metabolise drugs'.
3. to (5) The Chief Psychiatrist in consultation with the NSW Mental Health Clinical Advisory Council is currently considering these issues."


The classic Ponderers Response.

In the meantime, during the period of little ado about much, the occasional akathisia-induced homicide and suicides reach us through the press and the thermometer of drug-induced death continues to show a rise.

This is all happening in Australia too.
We need a False Claims Act and Qui Tam provisions. We have our Biedermans here and they need to be exposed,
TEXT FROM VERACARE: The program includes footage from the astounding videotaped deposition. In USA, a deposition is the evidence in chief for a court case, It is videotaped and circulated so that cross examination can be prepared.
http://www.youtube.com/watch?v=1TwdsYVHjGA

Dr. Joseph Biederman, the influential Harvard child psychiatrist whose financial relations with Janssen Pharmaceutica prompted Congressional investigation as they were deemed in violation of federal conflict of interest disclosure regulations.

The deposition includes a slide presentation in which Dr. Biederman promises Johnson & Johnson/ Janssen pharmaceuticals that his "planned studies of [the company's] medicines in children would yield results benefiting the company." The deposition also includes Dr. Biederman's assertion that his Harvard status ranks just below GOD...

Neither conflict of interest violations--nor the breach of scientific integrity in drug trials whose results were predetermined--resulted in any meaningful sanctions--either by Harvard or the National Institute of Mental Health--the federal agency that provided taxpayer support for Dr. Biederman's commercially driven drug research.

Thus, Dr. Biederman's self assurance may reflect his certainty that his privileged position is protected by the power structure.

Vera writes:(with some bitterness coming from experience) One is reminded of the ruling class of pigs in George Orwell' Animal Farm, who decree:

"All animals are equal, but some animals are more equal than others..."

FYI
Tonight Public Broadcasting (PBS) airs an investigative report about the drugging of children in foster care.
http://www.pbs.org/wnet/need-to-know/uncategorized/need-to-know-january-7-20

This is happening here too but minister is not hearing over the louder voices of pharma-educated psychiatrists. This is why DOCS is overflowing, either kids and mothers get medicines and become disturbed on them.

Question asked on 13 May 2010 (session 54-1) and published in Questions & Answers Paper No. 197 <http://bulletin/prod/la/lapaper.nsf/V3QnBySN/541~197/$file/197-QA-S.pdf> .
Answer received on 17 June 2010 and printed in Questions & Answers Paper No. 211 <http://bulletin/prod/la/lapaper.nsf/V3QnBySN/541~211/$file/211-QA-S.pdf> .10220—DEATHS DUE TO ZYPREXA AND RISPERDAL
Mr Daryl Maguire to the Deputy Premier, and Minister for Health—
1. Is the Minister aware that in Zyprexa and Risperdal clinical trials presented to the US FDA to get these drugs licensed, it was revealed that:
1. 1 in 208 (20) Zyprexa (olanzapine) subjects died;
2. 1 in 250 (12) risperidone clinical trial subjects died;
3. most of the deaths (21) were suicides?
2. Is the Minister aware of damages being paid to States and individuals consequent on litigation for fraudulent promotion of medication?
3. Is the Minister aware that by 2003, 288 deaths had been reported to the TGA of persons taking new "Atypical" drugs?
4. What warnings have been issued to patients and prescribers re the above drugs?
5. (a) Have these deaths been thoroughly investigated by coroners as they are in the USA, as described in the editorial provided to which an Australian (NSW) psychiatrist has contributed?
6. (b) Has an inquiry been made into what medications they were taking or had recently taken?

Answer—
I am advised:

(1) and (2) Agreement for drugs to be included for Australian use rests with the Commonwealth Government. The Therapeutic Goods Administration (TGA) regularly evaluates prescription medicines for quality and safety and to ensure that the product is effective for its intended use. NSW Health ensures that any warnings issued by the TGA are included in relevant clinical guidelines.

(3) The TGA's Office of Medicines Safety Monitoring receives reports of suspected adverse reactions to prescribed medicines, vaccines, over-the-counter medicines and complementary medicines.

(4) The TGA provides advice on suspected adverse reactions to prescription medicines to the public and prescribers as required. Information is available to patients and prescribers in the Approved Product Information leaflets on medicines approved in Australia.

(5) Questions concerning the Coronial Process should be directed to the NSW Attorney General.

TIME Magazine on Psych Drugs and Violence (Posting No. 1 of 2)

Top Ten Legal Drugs Linked to Violence

By Maia Szalavitz Friday, January 7, 2011

When people consider the connections between drugs and violence, what typically comes to mind are illegal drugs... However medications… like Prozac… have also been linked to increase risk for violent, even homicidal behavior.

A new study from the Institute for Safe Medication Practices published in the journal PloS One and based on data from the FDA’s Adverse Event Reporting System has identified 31 drugs that are disproportionately linked with reports of violent behavior towards others.

When one particular drug in a class of non-addictive drugs used to treat the same problem stands out, that suggests caution: unless the drug is being used to treat radically different groups of people, that drug may actually be the problem. Researchers calculated a ratio of risk for each drug compared to the others in the database, adjusting for various relevant factors that could create misleading comparisons.

(10) Desvenlafaxine (Pristiq) first metabolite of venlafaxine and produced by it, Antidepressant which affects both serotonin and noradrenaline, is 7.9 times more likely to be associated with violence than other drugs.

(9) Venlafaxine (Effexor) also used to treat anxiety disorders. Effexor is 8.3 times more likely than other drugs to be related to violent behavior.

(8) Fluvoxamine (Luvox) Antidepressant that affects serotonin (SSRI), Luvox is 8.4 times more likely to be linked with violence

TIME Magazine on Psych Drugs and Violence (Posting No. 2 of 2)

Top Ten Legal Drugs Linked to Violence

By Maia Szalavitz Friday, January 7, 2011

(7) Triazolam (Halcion) A benzodiazepine which can be addictive, used to treat insomnia. Halcion is 8.7 times more likely to be linked with violence than other drugs.

(6) Atomoxetine (Strattera) Used to treat attention-deficit hyperactivity disorder (ADHD), Strattera affects the neurotransmitter noradrenaline and is 9 times more likely to be linked with violence compared to the average medication.

(5) Mefoquine (Lariam) A treatment for malaria, Lariam has long been linked with reports of bizarre behavior. It is 9.5 times more likely to be linked with violence than other drugs.

(4) Amphetamines: (Various) Amphetamines are used to treat ADHD and affect the brain’s dopamine and noradrenaline systems. They are 9.6 times more likely to be linked to violence, compared to other drugs.

(3) Paroxetine (Paxil) An SSRI antidepressant, Paxil is also linked with more severe withdrawal symptoms and a greater risk of birth defects compared to other medications in that class. It is 10.3 times more likely to be linked with violence compared to other drugs.

(2) Fluoxetine (Prozac) The first well-known SSRI antidepressant, Prozac is 10.9 times more likely to be linked with violence in comparison with other medications.

(1) Varenicline (Chantix) The anti-smoking medication Chantix affects the nicotinic acetylcholine receptor, which helps reduce craving for smoking. Unfortunately, it’s 18 times more likely to be linked with violence compared to other drugs — by comparison, that number for Xyban is 3.9 and just 1.9 for nicotine replacement.

Read more: http://healthland.time.com/2011/01/07/top-ten-legal-drugs-linked-to-violence/#ixzz1APrGSh5M

I have had genetic tests performed for CYP450 metabolising enzymes, (2D6, 2C9 and 2C19) on over 100 normal folk had become suicidal and homicidal (and hallucinated) on antidepressants and antipsychotics or had other serious Adverse Drug Reactions (ADRs). I found that 98 could not metabolise these drugs because they lacked relevant genes. I have no tested Champix or Lariam subjects. Those with normal genes were on multiples of standard dose and polypharmacy, and their metabolism was overloaded, often with inhibitors of these metabolising enzymes. Most got polypharmacy (multiple drugs) as well, after they had become violent and suicidal, and it made their condition worse.
I have tested 10 formerly normal folk who killed mindlessly on anti depressants and all have serious genetic problems.
10 in a row is not convincing to some so I need more medication induced akathisia-homicide perpetrators and akathisia-suicide cases where DNA is still available. Whether these drugs cause suicide or homicide just depends on which way the gun is pointed. It is the same neurotoxic phenomenon. Akathisia.
This is a situation where the medical profession does not want to know, medical journals do not want to publish, and authorities do not want to hear. My colleagues and treat me with a 21st century version of how they treated Ignasz Semmelweiss who discovered in the mid 19th Century, before Pasteur, that doctors brought in unseen germs on their hands and fatally infected women during childbirth.
My experience with Zyprexa (olanzapine), Risperidal (risperidone) and Seroquel (quetiapine) is that they are as bad as Effexor in causing violence to self, causing suicide or homicide, as Effexor, but this gets blamed on the presumed "schizophrenia" being treated. Persons with mental illness were neither more suicidal or homicidal than the general population (there were no guards on psychiatric wards before Prozac) before we indiscriminately started to use medications that are catastrophic for the minority who carry these faulty genes while failing to recognise their adverse side effects the most dangerous of which is (recurring) akathisa,

"In times of universal deceit, TRUTH becomes a revolutionary act!" Who was it who said "...that for evil to prevail it takes a few good people to do nothing?"

Dr.Peter Breggin in the U.S. of America, Dr. David Healy in the U.K. and now at last a hero in Australia a champion of human rights and the right to informed consent, exposing the very information withheld from those treated involuntary without INFORMED consent.

Wake up Australia before your next prescription drug puts you over the edge...

"All that is necessary for evil to triumph is for good men to do nothing" has been attributed to Edmund Burke, the Irish political philosopher. A similar phrase is also in Leo Tolstoy's 'War And Peace'.

While there are some lawyers in Canada who are champions of informed consent no doctors have stood up against the system. It's about time because beautiful young people are dying in Ontario too often from suicide while taking SSRIs.

Grieving parents in Ontario last year succeeded in getting a coroner's inquest into their daughter's suicide which resulted in the jury making several good recommendations towards the prescribing of SSRIs but there is no guarantee that they will ever be implemented in practice. At least the general public in Oakville is more aware of the problem now because it was well covered in the media.

I understand that the cytochrome P-450 enzymes form part of the vital mitochondria which are vital for cell division and cell death and have their own DNA. Many chemicals are known to damage the mitichondria themselves and/or the vital proceses they control.
Mitochondrial damage has been linked to a host of illnesses, including cancers. For more information see http://mito.convio.net/site/R?i=dyW9g3FnZZnyjhI6Vl6I-g
or for a basic overview http://www.oprus2001.co.uk/mitochondria.htm

As I understand this the CYPs are not mitochondria or on mitochondria but are alleles which provide a position on the gene where a drug molecule fits and is demethylated or given a hook (Stage 1) and next stage of metabolism, (Stage 2) is UGTs which render it soluble and able to be excreted in bile or urine. Both systems are polymorphic i.e. different in every individual so ADRs are good for computers to analyse, If CYPs and UGTs are not all normal but are mutated, absent or different, the substrate drug does not get metabolised and its blood level reaches toxic levels and causes neurological, cardiac and other side effects. E.g those with diminished activity allele at 2C9 are vulnerable to heart attacks on NSAIDS as they get high blood levels of Vioxx. These heart attacks are not coronary vessel occlusions but are caused by a pathological prolongation of QT interval i.e. by changed conductivity or the wiring and the heart sometimes stops.

Very complex subject but cytochrome P-450 are most definately "not mitochondria or on mitochondria" but they are IN the mitochondria.
"Human CYPs are primarily membrane-associated proteins, located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. "
Without properly functioning mitochondria we are all in trouble and so any chemicals that damage the mitochondria and DNA or RNA are bad news....

Interesting quote from RBruce UK.

In case its useful its from

"An overview on the allelic variant of CYP2D6 genotype"
by Shiju Mathew in 'African Journal of Biotechnology Vol. 9 (54), pp. 9096-9102, 29 December, 2010
Available online at http://www.academicjournals.org/AJB
ISSN 1684–5315 © 2010 Academic Journals

Or here's the pdf version at: http://www.academicjournals.org/AJB/PDF/pdf2010/29Dec%20Special%20Review/Mathew.pdf

The quote RBruceUK used can be found on Page 4.

Quote from a standard dictionary of Biology.
"Cytochromes - located in the inner mitochondrial membranes"
Interestingly the proteins are light sensitive and a specialist demonstrated recently how his life as a General Practitioner changed when he noted that when a light was shone on the skin of the arm there were changes to the heart beat.
In the mitochondria minute electric currents are involved in the ATP/ADP energy cycle that controls respiration and therefore heart rate. Linked to that is the cyclic AMP that is necessary for hormone utilisation.
It has been admitted that chemicals such as the organophosphates can harm the mitichondria and that one of the results of the damage caused is a delay in the mechanism of the heart, among many other cardio-respiratory effects as reported by Ballantyne and Marrs. This combined with the known effects of chemicals and drugs on the cytochome P-450 which alone can increase susceptibility to pharmaceuticals by 40-fold may explain all of the dangerous reactions to treatments and such deadly problems as Cot Death, Adult Sudden Death Syndrome, Chronic Fatigue Syndrome and Multiple Chemical Sensitivity. A useful list of drugs and their effects in those with damaged mitochondria is to be found at www.MitoAction.org

I am a scientist with thirty years experience in Biochemistry and Molecular Genetics. My personal scientific interest is in the individual responses to the development of toxicity in response to biologically active molecules, including drugs. I have extensive experience working in drug and toxicology laboratories.

Pharmacogenetic studies relating to psychotropic drugs have generated a great deal of information

The main background points arising from this knowledge include the following:

• Despite increasing choices in medication management, many patients on psychotropic medication still experience poor outcomes related to inadequate medication response and significant adverse drug events, including neurotoxicity.

• Psychiatric medications may exhibit toxicity not only on the basis of their therapeutic use but also (and mainly) on the basis of their pharmacokinetic (what body doing to drugs) and pharmacodynamic properties (what dugs doing to body).

• Individual variations in drug pathways influence the responses of a patient to treatment with psychotropic drugs. Children, woman and adolescents with metabolic polymorphisms may be at greater risk for adverse drug events than individuals with normal metabolism (ability to eliminate toxins or drugs).

• Psychotropic drug prescribers should consider treatment-resistant patients as potential abnormal metabolisers. Nearly 80% of all drugs in use today, along with most psychotropics, are metabolised via testable metabolic pathways.

• Patients with psychiatric disease are at increased risk for being on multiple medications and complex regimens, which makes them particularly vulnerable to drug interactions, with the consequence of developing toxicity.

• Clinicians response to treatment resistance is to optimize dosing in their treatment of psychiatric symptoms. They may incorrectly conclude that the patient is just anxious or dramatic. However, in the abnormal metabolisers population, so called “somatic symptoms” associated with psychiatric diagnoses may in fact be medication intolerance exacerbated by dose titration.

Part 2
Adverse Drug Reaction manifestation (appearance):

Psychotropic medications have been associated with a variety of Adverse Drug Events (ADEs), including neurotoxicity development. Wall et al, 2010 (Mayo Clinic USA) created a list of Adverse Drug Reactions that have been linked to abnormal metabolism of psychotropics:

From Wall et al (2010)
ADVERSE EFFECTS ASSOCIATED WITH ABNORMAL METABOLISM 13-51 references:

Reduced metabolism (ie, poor):
Extrapyramidal Symptoms 14-22, Tardive dyskinesia14,34-36, Oversedation 38-40, Cardiovascular complications (ie, tachycardia, hypertension, hypotension) 46,47, Weight gain 46,47, Neuroleptic malignant syndrome 48-50, Serotonin syndrome 51, Suicidality 22,51

Increased metabolism (ie, ultrarapid): Opioid toxicity 23-33, Nausea 37, Paradoxical excitation 41, Treatment nonresponse 43-45, Suicidality 13

Individual responses to treatment:

The genes that code for the enzymes involved in the metabolism of drugs are highly polymorphic and appear to be highly variable between individuals. The most commonly studied cytochrome P450 (CYP) enzymes include 2D6, 2C19, and 2C9. Polymorphisms and gene duplications in these enzymes account for the most frequent variations in phase I metabolism of drugs since nearly 80% of all drugs in use today, along with most psychotropics are metabolized via these pathways.
According to our data published in Pharmacogenetics in 2009 patients with drug-induced akathisia have a high prevalence of the abnormal metabolisers genotype.
I believe that pharmacogenomic testing has a significant role in modern psychopharmacologic practice and that the accumulated knowledge has the potential to fill some of the scientific uncertainties in neurotoxicity interpretation.

Part 3
We need new approach in medicine development which allows us to:
- develop precise and clear recommendations for practitioners with an evaluation of benefits verses harm for different groups of antidepressants and psychotropic drugs
- to stop speculation in the media and in other publications about drug toxicity and promote the benefits of an individual approach to treatment
- to promote warnings about the different reactions that different people can have to antidepressants and psychotropics
- to avoid clinical malpractice lawsuits for hospitals and practitioners. Given that some pharmaceutical companies already provide this information, sooner or later such cases will be the subject of liability for medical practitioners.
- Medical practitioners, psychiatrists and caregivers should be involved in the treatment regime and should be aware of the signs of the development of the adverse drug reaction

As Dr Francis Collins said: It is predicted that within 10-20 years systems medicine will prevail in the form of P4 Medicine:
1. Predictive (from the genetic background information)
2. Personalised (individualised treatments)
3. Preventative (using the knowledge of the individual predisposition)
4. Participatory (patients/caregivers should participate in the treatment)
Participation of doctors, caregivers and patients in treatment should be part of the medical program and we already have the scientific and technical background to support this new development.

To Yola and Bruce UK,
You are both right, but you are talking about different levels: Bruce about ‘inside’ cells processes, Yola about ‘outside’ cells processes.
Inside cells: cytochrome enzymes are located on the inner mitochondrial and endoplasmic reticulum membranes.
Outside cells: gene expression differs in different tissues depending on the type of cytochrome and tissue type.
Cytochrome P450 is a very large complex of proteins, which located in all cells; however, they have different function in specific tissues.
We are talking here about Phase I liver detoxification system cytochromes.

Thanks to Yola and Irina for their expertise and scientific information on this complex subject.
However. I must ask if we can really look at the inner and outer systems in isolation.
The mitochondria take part in cell production and survival and therefore they influence the properties held within and by the cells they produce.
The various forms of RNA and DNA work together to reproduce themselves and make the very proteins and enzymes required for that process.
"Major enzyme complexes found in the inner mitochondrial membrane are synthesised part on mitochondrial ribosomes and part on cell sap ribosomes" - proteins are manufactured by cells on the ribosomes and the entire system is dependent on the energy produced by the mitochondria, which employ natural bonds with phosphates.
The enzymes are themselves proteins. The cytochromes are proteins. Many hormones are proteins and utilise cytochrome P-450 enzymes.
All must be in homeostasis and all chemicals disrupt that balance to various degrees.
Recent research suggests that cells can detect nutrients in food and that even this can influence hormones.
Drugs and chemicals that bind to the mitochondrial ribosomes and interfere with mitochondrial protein synthesis cause toxicity to mammals.
"endocrinology disorders, and exposure to toxins are among the many medical problems that can cause mental impairment, depression, anxiety, delusions, hallucinations, aggressiveness and a variety of other psychological symptoms and syndromes." - Abnormal Psychology 1995.
The drugs act on the same sites as the poisons and none of this knowledge is new. “The Biochemistry of the Nucleic Acids” was first published in 1981 and has sections on gene mutation and recombinant DNA technology.
Perhaps eliminating the poisons should be the first step to solving this problem?

Richard has a very good point here: organism is a complex mechanism and all processes are related. However, cytochrome P450 system is the first line of defence in detoxification system. Hence, all impairments in this system should be taken in consideration. (most important they are easy detected and can be used in clinical practice). Phase 1 cytochrome P450 loss-of-function polymorphisms should be included in patient record warning labels, similar to allergies, as a warning that an individual patient is susceptible to adverse drug reactions or has a limited capacity for elimination of toxins, leading to the development of allergies or toxicity. In addition, this system participates in the metabolism of environmental toxins making individuals with loss-of-function polymorphisms susceptible to the development of allergies and metabolic diseases.

I recall a bright drug user with a drug induced psychosis to speed saying to me;

"Surely you are not going to treat a toxic state with another toxin."

He was of course right and I did not.

Just gave lots of fluids gave lots of fluids, and he detoxed faster than he might have done with Risperdal or Zyprexa which need the same metabolic pathways as amphetamines.

Since then I learnt that those who get toxic psychosis on amphetamines whether they were illegally obtained or prescribed, also have diminished CYP450 metabolism genes and get worse if you give them more drugs.

Time and talking them down fixes it.

The drug culture knows this but psychiatrists do not.

I don't know if parts of this group of videos might also be useful to Bruce (Richard?).

Its a kind of lecture in 13 bite-sized chunks with the last few being the lecturer answering questions by members of the 'audience'.

This is the video of Part 1 of 13
Dr. Veltmann, Personalized Genomics

http://www.youtube.com/user/iimsite#p/u/12/plgmnlpq4Xc

If that looks as if it might touch on areas Richard is referring to, then the complete set of videos in numerical order is here:

http://www.youtube.com/results?search_query=iimsite&aq=f

WHOOPS! I think its Video number 2 that I have a feeling MIGHT touch on what Richard is saying because Dr Veltmann goes into how environmental factors and nutrients can change phenotypic expression.

I'd watch Video 1 first anyway as its more of an introduction and leads up to Video 2, as it may have some of this nutrient and environmental in it as well (tired and can't remember clearly, sorry) and I might be completely on the wrong track as to whether its pointing in part to what Richard is saying, but here's a link to Video 2 (or Part 2) anyway:

http://www.youtube.com/user/iimsite#p/u/3/xWmC4Z7dnYw

This issue is much more complex than personal genomics, and the chemical companies have been utilising the science to develop their drugs and industrial/agricultural chemicals for decades.
Sadly the approvals system prioritises proof of beneficial effects on the problem to be treated, but suppresses or hides the adverse effects that are triggered by those same chemicals that may even lead to deaths.
Protein creation, and enzyme blocking or bonding mechanisms are the basis for all these reactions and there are few, if any, chemicals that have only one effect.
“Proteins carry information in their shape and chemical structure: change either of these and you change the information carried by the protein… Nature’s favourite way of changing the shape or chemical structure of a protein is to stick a phosphate group onto its surface or to remove one …”
Frequently generic chemicals have different properties and side-effects to branded versions because of actions triggered by other chemicals in the formulations and additionally the very detox mechanisms that are there to protect us can themselves convert the poisons into even more toxic substances that will bond to and disrupt other vital enzymes as metabolites are formed.
All this is known but studies of proteomics and genomics are mostly used to find new drugs and chemicals to solve the problems caused by the initial disruption of the system.
Although the study of Epigenetics is growing in importance there is very little research being done to determine the actual cause of the genetic and protein mutations that have triggered the problems and when causes are found, as in the pharmaceutically-induced iatrogenic cases of CJD via the injection of mutated proteins into healthy people, (and the TGN 1412 drug trial disaster), every effort is made to suppress the truth in order to protect industry.
Effects of toxins on the mitochondria, proteolytic enzymes, and the various forms of RNA and DNA, can have devastating results, triggering such diverse illnesses as Schizophrenia, Parkinson's, cancers, etc., and the very anomalies with the detox and control systems discussed here that are designed to prevent such problems.

Is it life threatening if a person in a very toxic state is repeatedly treated with another toxin?

I trust the doctors here for a clear answer and not in jargon please.

The posts about death statistics overwhelm me at times because so many of the people I know are drugged with prescription medication. Often with debilitating side effects.

You people have the answers and still nothing is happening!
How can we change things? Perhaps the hope that good will conquer evil
but in our world today it's a big ask but if we lose hope we are lost.

Beth - I am not a doctor, but I would think the answer to your question "Is it life threatening if a person in a very toxic state is repeatedly treated with another toxin?" would have to be Yes.

For example:

http://www.firstconsult.com/das/pdxmd/body/235308051-43/0?type=med&eid=9-u1.0-_1_mt_1010017

Re Life threatening Neuroleptic Malignant Syndrome from dopamine-blocking medications, antipsychotic agents.

http://www.nytimes.com/2007/02/27/health/27brody.html?ei=5124&en=4debc4fa3f838779&ex=1330837200&partner=permalink&exprod=permalink&pagewanted=print

Re Life threatening Serotonin Syndrome from drugs that raise serotonin levels, SSRI antidepressants and some others.

http://www.countercurrents.org/pringle080507.htm

Re Doctors failing to recognise life-threatening serotonin syndrome and how "medical experts are "scrambling to educate doctors" about this.

Very good question - Why do doctors not recognise and act on the knowledge of these effects and potentially fatal reactions?
There are many who monitor this forum who can give the answer but sadly if they do those who have a vested interest in hiding the dreadful truth will target them.
Here in the UK many patients have tried to persuade the General Medical Council, Members of Parliament, and the Police to investigate the doctors who have hidden cases of poisoning by drugs, pesticides and vaccines and fraudulently blamed the symptoms on mental illness but the GMC and all other authorities, including the Police, have refused to get involved.
Should doctors speak out, expose the wrong doing, and offer alternative treatments they will find that those same powerful forces will turn on them in attempts to limit the damage to powerful international companies, which have, via the approvals and licensing systems, passed liability for faulty product to the various governments, which in turn accept safety data without ever checking them for accuracy.
The only way that these crimes against humanity can be exposed is through the media and the courts but they too are controlled, as many of us have found to our cost.
We can only hope that the many honest but fearful doctors and scientists in this world will find a way to counter the power and get the information to the patients who need to know – for their lives, and sanity, depend upon it.

"We can only hope that the many honest but fearful doctors and scientists in this world will find a way to counter the power and get the information to the patients who need to know – for their lives, and sanity, depend upon it".

Yes RBruceUK - I hope everyone here agrees that so many lives do depend on fearful doctors and scientists countering the power and getting the information to the patients.

When they find the courage they will also find a way to take a stand alongside the lone brave individuals like Yola and take the huge step it must take in this day and age to become true to themselves and to what they once believed in, which in medicine is to "Above all, Do No Harm".

bruceUK,

I am very interested in epigentics but have trouble getting answers even from Karolinska, I know a person, a Poor Metabolizer 2D6*4*4 who was toxic on paroxetine then high dose venlafaxine for years and gave birth to a child with Angelman's syndrome, genetic proof, having taken paroxetine throughout her pregnancy. One of my books says Angelman's syndrome is an epigenetic problem.

The child has, without detailed examination, the same heart and head bone problems as Paroxetine babies have, will not go into detail here. Can you advise where I can learn more about this, and thank you for your contribution.
I value your opinion please and sources of further information

Epigenetics has been developing since 1947. Now seems more focused on causal interactions between genes and their products and the changes in cells and formation, which can be transmitted through the generations. Defined as “the study of heritable changes that occur without a change in the DNA sequence”.
Over 5 years ago a UK study on Epigenetics reported that environmental influences over our grandmothers when they were still in their mother's wombs (the eggs are viable) and those same influences over our grandfathers at puberty can trigger changes in the genetic makeup that will be passed down for generations to come.
Another example of drug induced effects on the unborn is DES.
DES (diethylstilbestrol) was a synthetic oestrogen regarded as a wonder drug used to prevent miscarriages and premature births in an experiment on some 5 million women. It was intended for routine use in all pregnancies and for menopausal symptoms, acne, prostate cancer, gonorrhoea, as a growth regulator to slow girls who were growing too tall and as a "morning after pill", even as a food additive on farms.....Then rat studies began to show abnormalities.
Rare vaginal cancers began appearing not in the treated women but in the teenage children born to them.
Later it was suspected of causing fertility and immune system problems and testicular cancer in male children also born to treated mothers. Daughters of treated women were reported to show permanent changes in the T and natural killer cells of the immune system and yet they did not show greater vulnerability to infection.
The claim was that the delayed long-term effects that did not show until later in life were previously unrecognised medical phenomena.

http://en.wikipedia.org/wiki/Epigenetics

Bruce You might be interested in this response from Wendell Weber to the same question:Next thing is to find paroxetine affected progeny and see if they have Angelman's syndrome
You asked 1) whether Angelman's syndrome (AS) is an epigenetic
problem, and 2) whether paroxetine in a homozygous CYP2D6 poor
metabolizer (allele 4:allele 4) with or without alcohol intake can cause AS?

As to the first question: The review by B. Horsthemke and J. Wagstaff
(2008) that considers "Mechanisms of imprinting of the
Prader-Willi/Angelman region" states that AS is a distinct
neuodevelopmental disorder caused by several genetic and epigenetic
mechanisms caused by several genetic and epigenetic mechanisms
involving the proximal arm of chromosome 15. Lack of a functional
maternal copy of ubiquintin ligase 3A (UBE3A), a gene within
chromosome 15q11-q13, causes AS. Individuals with AS exhibit
microcephaly, ataxia, severe mental retardation, seizures, absence od
speech and sleep disorder (CA Willaims et al, 2006). Seventy percent
of AS individuals have large de novo deletions of 15q11-q13, but in
AS individuals, these de novo deletions are always of maternal
origin. Five to 10% of AS individuals have point mutations 0f the
UBE3A gene within 15q11-q13 which has led to identification of UBE3A
as the AS gene. Three to 5% of AS individuals have an imprinting
defect, wuith a meaternally inherited chromosome 15 that has a
paternal imprint, and 1-2% of AS individuals have paternal
uniparental disomy of chromosome 15. There are still a number of
major unanswered questions about the imprinting process which
Horsthemke and Wagstaff discuss.

As to the second question: I have done a Google search looking for a
causative link between paroxetine-induced birth defects (in the
presence and absence of alcohol intake) and AS. Those searches were
not exhaustive but insofar as they went, they did not yield any
useful information. Despite that negative information, they do not
necessarily rule a possible connection

I hope these comments are a some help in response to your queries

There is an interesting article on Angelman Syndrome here

http://en.wikipedia.org/wiki/Angelman_syndrome

A surprisingly recently reported genetic effect. 1960s onwards it seems.
Perhaps an early result of chemically induced DNA damage and the Epigenetic link is certainly noted - "this is due to gender-related epigenetic imprinting " ?
Interesting too that Ubiquitin pathways are involved as they play a role in removing defective and excess proteins.
The drug is reported to bind to proteins and to be linked to effects in many organs and energy systems so it would seem likely that there would be some transfer of effect to the foetus?
"safety in pregnancy not established" - BMA.
Whether or not such effects could trigger a genetic effect is for science to determine.

clearly the big pharma lobby has no moral guidance
and will do anything it can lobby to get more cash

its power is obvious simply in the pricing
their power to corupt is revealed in govt subsidising their gain[pbs]

the true measure of a drugs agffectivness is a thing called 'dose needed to cure number'..that generates a ratio of

how many need to take a drug
for one cure

it would come as no surprise that they hate this nmumber
this number reveals[for egsample] that with stroke medication

60 need to take the 'drug'
[heavilly govt subsidised drug]..to get one* cure

and that is how most drugs are

thus we need to be far more conceerned about adverse reactions[to perscribed drugs ..that is the cause of 1 in 100 hospital admissions
[1 in 10 resulting in death]

''doctor education in order to minimise promiscuous and uninformed anti-depressant prescribing.""

this is non egsistant
how many times you watched the quack read his drug bible
to perscribe a drug he dont know nuthin about[hasnt even read the leaflet that comes sometimes in the box[other times in the carton]but not read by anyone

''her complaints,findings and warnings about lack of action,""
is typical

""lobbying her colleagues,the Medical Board and the Health Care Complaints Commission of NSW, the Adverse Drug Reactions Advisory Committee(ADRAC)of the federal Therapeutic Goods Administration and a clutch of ministers, both state and federal""

is equally futile
heck they banned nicoteen in tobacco
[taxed it out of egsistance]

WHILE GETTING A NEW SUBDIDY on it
in patches and chewing gum

plus other 'stop smoking' drugs
soon they will outlaw alcohol[and get a govt subsidy to sell it]

see their money can buy any govt
any party ..any media..any watchdog

http://snardfarker.ning.com/profiles/blogs/data-shows-flu-vaccines-double?xg_source=activity

What was a bit surprising

..when we looked
...that people who have* been vaccinated
...seemed to have twice the risk of getting swine flu

http://snardfarker.ning.com/group/flu

re ..nnt number
the Number Needed to Treat (NNT) is the number of patients you need to treat to prevent one additional bad outcome (death, stroke, etc.).
http://en.wikipedia.org/wiki/Number_needed_to_treat
search result
http://www.google.com/search?hl=en&q=number+needed+to+cure+number&btnG=Search&aq=f&aqi=&aql=&oq=

The higher the NNT,
the less effective is the treatment

http://www.medicine.ox.ac.uk/bandolier/booth/glossary/NNT.html

See also
Number needed to harm
http://en.wikipedia.org/wiki/Number_needed_to_harm

— the converse for side-effects

so the trick is compare two dogs[bad mediSines]
then claim this is best..because it beat the other dog

guess who choses
which dog compares with which dog?

The hidden tyranny: children diagnosed
and drugged for profit

Monica G. Young
Natural News

Not everyone has fallen for the grand hoax: 20 million kids worldwide diagnosed with mental disorders, necessitating psychiatric drugs for years or life.

Some individuals are speaking out. Yet so many parents, kids and schools have fallen prey to one of the most insidious yet most profitable misinformation campaigns of modern society...

http://www.activistpost.com/2011/03/hidden-tyranny-children-diagnosed-and.html

http://femalefaust.blogspot.com/2011/03/reclaim-cyber-commons.html
Reading comment threads on the Guardian’s sites and elsewhere on the web, two patterns jump out at me.

The first is that discussions of issues in which there’s little money at stake tend to be a lot more civilised than debates about issues where companies stand to lose or gain billions: such as climate change, public health and corporate tax avoidance.

These are often characterised
by amazing levels of abuse and disruption.

"These are often characterised
by amazing levels of abuse and disruption."

And so they are. To the detriment of everyone.

In the big Pharma industry are the workers ( not all researchers and top executives) but people on the ground aware of what they are doing?
It is difficult for me to comprehend so many people are uncaring. Do these companys pay their staff above award wages? Please tell me how
innocent caring people get caught up in these terrible atrocities.

Interesting question Beth. Do doctors and their nursing staff who are employed by the state in your local hospitals actually know-what-they-are-doing? Does your local doctor, your general practitioner, your GP actually know the effects of the psychotropic drugs he or she prescribes? In the Pharma industry, the psycho-pharmacists who design the drugs, do they know exactly what their creations actually do and/or are used for in the real world?

Do they comprehend that some psychiatric drugs are intentionally-used-in-overdose-as-torture? Do they know their drugs are used quite deliberately for uses other than that specific use for which they have been designed and authorized and indeed have been specifically licensed for? Do they realize the lethal damage they inflict upon patients who are made to become suicidal on these products, patients who they have forced to take drugs; but drugs that make them want to kill themselves?

What about if a patient assaults a doctor because the doctor refuses to stop the lethal drugging? Despite the fact the patient has begged the doctor(s) to stop the drugging time-and-time-again but to no avail? What then if the doctor presses charges and further-forced-drugging-is-authorized by a court and at heavier doses exceeding the genetic maximum in a jail hospital?

What then is to be done when it is documented that a patient has been force-drugged for a year and then is released alone but three days later is found-dead-from-suicide? Who is responsible? Who is to say it was not intentionally induced? What then if evidence-is-refused to be heard at inquest? After all before the fatal release it certainly was documented that the akathisia-was-expected to occur on the morning of the day of the suicide. Would all this not indicate a drug-induced-death? Whatever else might have caused such a situation to end so tragically? And of course to be left to remain unresolved because it was not properly investigated?

Is there a pattern here? How often do hospitals and doctors allow such adverse-drug-reaction-events to occur? Without my having even mentioned cytochromes and poor metabolizers or drug-drug-interactions, is this-standard-psychiatric-practice?

ByTheWay29, As one who has suffered and survived SSRI and mood stabilizers and anti-psychotic drugs thanks to Dr. Lucire helping me withdraw safely. It is astonishing that even people that knew me before and see the remarkable difference in my life now, still continue to believe everything they are told by the medical profession without ever questioning. We need general practitioners and specialists in all fields but we must keep an open mind and listen and then decide if a particular course of
treatment is going to be beneficial or harmful to each of us as individuals. It would be tragic if a person had no trust at all in
the medical profession and died of a heart attack or something because they would not attend a hospital.
This situation with the Big Pharma is like my worst movie but it is real. All your questions are so valid but horrifying.
Do you think the answers will be resolved in our life time?

"There will be,...in the next generation..or so,
a pharmacological*method*..of making people love their servitude,

and producing dictatorship..without tears,so to speak,..producing a kind of painless..concentration-camp..

*for entire societies,

so that people will in fact..have their liberties taken away from them,but will rather enjoy it,..because they will be distracted from any desire to rebel..*by propaganda or pills..

or brainwashing enhanced

*..*!..*by pharmacological methods.*!*!*!

And this..seems to be
the final revolution.""

*SUBSIDISED*
BY GOVT subsidies...!

http://mp3.oraclebroadcasting.com/Intel_Hub/Intel_Hub.2011-02-28_16k.mp3
http://www.youtube.com/watch?v=PTc5mNp3EvE
http://globalresearch.ca/index.php?context=va&aid=23424

And please don't forget:

financial institutions
love GOVT TAX funds]..

no matter who wins or loses,
debt is incurred,and must be repaid!

http://globalresearch.ca/index.php?context=va&aid=23443

we are governed by tools
fools and imbisiles

who read prepaRED SPEACHES
little knowing what their own words reveal

may satan have mercy on their souls

they chose
their own version of hell

those who regulate..by the law
shall be ruled ..under the same ..form of law

as ..they thought to rule others by

thus the mad ..make bad law
..built on spin and lie
but OCCASIONALLY a truth gets out

Laurie Ferguson..[quote]

{smoking is atributable to}..
""...*20 per cent..!
of all cancer-deaths..in general""

http://www.openaustralia.org/debates/?id=2011-02-28.44.2

but this knowing
still gave a new tax on smokers
via lies

the deciete and collusion
will remain unconditional..binding upon them*

for eternity

enough said
http://revolutionarypolitics.tv/video/viewVideo.php?video_id=14151
http://www.marketwatch.com/story/recovery-ends-if-debt-limit-not-raised-bernanke-2011-03-01?siteid=rss
http://dailybail.com/home/is-ge-the-real-reason-paulson-panicked-in-the-aftermath-of-l.html
http://whatreallyhappened.com/WRHARTICLES/wildbankers.php
http://whatreallyhappened.com/es/content/ever-wonder-why-european-banks-were-so-angry-us-something-about-not-making-good-some-toxic-g
http://www.washingtonsblog.com/2011/02/government-is-trying-hard-to-convince.html
http://www.youtube.com/watch?v=vCXGSA-FydU
http://www.youtube.com/watch?v=JLx5BwebIDo

rip

an instrument of class warfare,

organized..and
designed to permit an elite,
local and multinational,duel-passportholder's..
to operate without any constraint from democratic processes.

This allows the bulk of the population
to be treated as a mere cost of production."--

Edward Herman,
economist and media analyst

....Who Will Be
the Most_Dangerous Man..In The World?

DICTATORSHIP

He has no guilt about the very real pain
that he has caused,by his words and works

whether it is ill-gotten gains, or death-tolls...
or process..or govt..or sense and sensabilties

He is excited by instant gratification,
which gives him more financial..or political power...
or even simple honours accorded him by sheep..

He is extremely smart..and knows how to scheme
and spin situations in his favor...
or others disfavour

He is someone..that is deeply involved
in the business-machinations of debt and war...
media/medicine/science and public relations
[spinning its selective authoritive spin selectivly]

He has an arrogant attitude,is allways wanting to be seen as right
because he is thoroughly indoctrinated into the machine...
they often tell him..he must be right..

yes-men
can be so ignorant

He is one of the most ardent
and fervent supporter..of this globalist cabalistic machine...
that rots the head..with eternal visions of his need
not seeing..his own greed directly created the need

He is closed off to the truth or opposition
and has pushed away those who loved him...who reveal truths
and suppresed any who would stand against him...and now cannot concieve the most obvious truths..cant tell his truth from his lies
has become enslaved to his own spin and lies..

He has committed legalized crimes against humanity...
suported exploitation of people or resourses human invention and sustainabilty of the whole

even using the most vile systems of oppression
and dictators sadists popularists and overblown ego's

He believes that the ends justify the means.
that the bottum line dont lie

He believes that might makes right.
that histry is wrote by victory

He sees the end of the lie..
but fails to see he is the one lying.

[if only to himself]