The Forum > Article Comments > Whistleblower in Coventry: Dr Yolande Lucire and Big Pharma > Comments
Whistleblower in Coventry: Dr Yolande Lucire and Big Pharma : Comments
By Peter King, published 20/12/2010For standing-up to non evidence-based medicalisation of her patients Dr Yoland Lucire is being persecuted by the NSW Medical Board.
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Posted by foucault, Wednesday, 12 January 2011 12:06:37 PM
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"All that is necessary for evil to triumph is for good men to do nothing" has been attributed to Edmund Burke, the Irish political philosopher. A similar phrase is also in Leo Tolstoy's 'War And Peace'.
While there are some lawyers in Canada who are champions of informed consent no doctors have stood up against the system. It's about time because beautiful young people are dying in Ontario too often from suicide while taking SSRIs. Grieving parents in Ontario last year succeeded in getting a coroner's inquest into their daughter's suicide which resulted in the jury making several good recommendations towards the prescribing of SSRIs but there is no guarantee that they will ever be implemented in practice. At least the general public in Oakville is more aware of the problem now because it was well covered in the media. Posted by bob47, Friday, 14 January 2011 8:39:35 AM
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I understand that the cytochrome P-450 enzymes form part of the vital mitochondria which are vital for cell division and cell death and have their own DNA. Many chemicals are known to damage the mitichondria themselves and/or the vital proceses they control.
Mitochondrial damage has been linked to a host of illnesses, including cancers. For more information see http://mito.convio.net/site/R?i=dyW9g3FnZZnyjhI6Vl6I-g or for a basic overview http://www.oprus2001.co.uk/mitochondria.htm Posted by RBruceUK, Monday, 17 January 2011 5:32:51 AM
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As I understand this the CYPs are not mitochondria or on mitochondria but are alleles which provide a position on the gene where a drug molecule fits and is demethylated or given a hook (Stage 1) and next stage of metabolism, (Stage 2) is UGTs which render it soluble and able to be excreted in bile or urine. Both systems are polymorphic i.e. different in every individual so ADRs are good for computers to analyse, If CYPs and UGTs are not all normal but are mutated, absent or different, the substrate drug does not get metabolised and its blood level reaches toxic levels and causes neurological, cardiac and other side effects. E.g those with diminished activity allele at 2C9 are vulnerable to heart attacks on NSAIDS as they get high blood levels of Vioxx. These heart attacks are not coronary vessel occlusions but are caused by a pathological prolongation of QT interval i.e. by changed conductivity or the wiring and the heart sometimes stops.
Posted by Yola, Tuesday, 18 January 2011 2:12:56 PM
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Very complex subject but cytochrome P-450 are most definately "not mitochondria or on mitochondria" but they are IN the mitochondria.
"Human CYPs are primarily membrane-associated proteins, located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. " Without properly functioning mitochondria we are all in trouble and so any chemicals that damage the mitochondria and DNA or RNA are bad news.... Posted by RBruceUK, Tuesday, 18 January 2011 8:39:14 PM
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Interesting quote from RBruce UK.
In case its useful its from "An overview on the allelic variant of CYP2D6 genotype" by Shiju Mathew in 'African Journal of Biotechnology Vol. 9 (54), pp. 9096-9102, 29 December, 2010 Available online at http://www.academicjournals.org/AJB ISSN 1684–5315 © 2010 Academic Journals Or here's the pdf version at: http://www.academicjournals.org/AJB/PDF/pdf2010/29Dec%20Special%20Review/Mathew.pdf The quote RBruceUK used can be found on Page 4. Posted by Zappp, Saturday, 22 January 2011 10:34:41 PM
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Dr.Peter Breggin in the U.S. of America, Dr. David Healy in the U.K. and now at last a hero in Australia a champion of human rights and the right to informed consent, exposing the very information withheld from those treated involuntary without INFORMED consent.
Wake up Australia before your next prescription drug puts you over the edge...