There is a simple guaranteed solution to the drug problem in Australia.
It requires two processes to occur.
First we need political will to create the legal framework necessary to achieve the required outcomes.
Secondly we need a robust and proactive law enforcement process.
The drug empires work on a simple pyramid plan of action.
At the bottom of the pyramid there are the users, mainly addicts
The second level is the street dealers who supply the addicts
The third level is the street level suppliers who feed the street dealers.
The fourth level is the street wholesalers who supply the street suppliers.
As the levels of activity increase so too do the numbers of participants decrease and the profits increase.
The fifth level is the bulk wholesalers that supply the street wholesalers.
The sixth level is the importers and manufactures who supply the bulk wholesalers.
The seventh level is the growers, cartels and laboratories
The apex level is the financers who reap the major profits.
So what is the answer?
Simple:
First you legislate to force people to answer truthfully. (Much the same as a Royal Commission)
Then you arrest the users and addicts and you force them to tell where they are getting supplies.
Then you arrest the second level street dealers and you coerce them into telling you where they get their supplies.
And so on up the supply pyramid until you reach the top level.
Problem solved.
However it is not so easy because you find that at the top level there interested parties that will not want to be publicly identified. Many of them will be so called upstanding members of the community.
They will lobby politicians, parliaments and police to protect their identities and their profits.

First of all we have to get a Prime minister like Duterte in the Philippines & put his Action Plan into action.

Your plan won't work. You'll find many people would rather go to prison than answer truthfully.

Also I think you've misunderstood the shape of the industry. There are rarely so many levels and in terms of profitability, the growers are never on a par with the cartels. I don't think the labs are either.

If you really want to kill the drug empires, the best solution is to enable the legal supply of drugs so that nobody has to resort to the illegal system. But politically that's too hard because it's seen as encouraging drug use.

I am with Aiden. There are few Mr Bigs or big gangs. Mostly it is chaotic criminals who waste the money and do drugs themselves.
It would make more sense to offer daily Stupor or elation to the addicts.
The only proviso should be that they practice birth control. It would cost very little and divert all the profit from drugs.
Let's do it!

chrisgaff1000,

Agreed.

General comment
A useful article,
http://www.smh.com.au/national/health/behind-australias-love-affair-with-illicit-drugs-20150424-1msnzz.html

However organised or disorganised the drug business, and however many levels, this suggestion falls over at the first step. It's not possible to legislate to make people tell the truth. Royal commissions can't do that, even torture can't do that.
The only method is legislation, regulation and a really serious approach to treatment and rehabilitation. You don't want more regulation? Well put up with the illegal trade and its terrible consequences, it's the ultimate free enterprise market.